围绝经期妇女重度抑郁症综合康复治疗的临床疗效分析

Analysis of the clinical effect of comprehensive rehabilition therapy in the treatment of peri-menopausal women with severe depression

目的探讨围绝经期妇女重度抑郁症综合康复治疗的临床疗效。方法对26例围绝经期重度抑郁症妇女给予服用尼尔雌醇、氟西汀、解郁汤及心理治疗,采用汉密尔顿抑郁量表(HAMD)和自评抑郁量表(SDS)评分进行治疗前后对比观察和治疗效果评价,同时检测血清雌二醇(E2)、血清促卵泡素(FSH)含量变化。结果经过8周的综合康复治疗后,患者E2水平明显增高(P<0.01),FSH含量显著降低(P<0.01),HAMD和SDS评分明显降低(P<0.01)。26例患者经治疗后,治愈16例(61.5%),显效6例(23.1%),有效4例(15.4%),总有效率为100%。结论综合康复治疗围绝经期妇女重度抑郁症疗效好、副作用小,是安全有效的治疗方法。

Objective To explore the effect of comprehensive rehahilitation therapy （famale hormone, antidepression medicines, Chinese medicines and psychological interference） in the treatment of pefi-menopausal women with severe depression. Methods Twenty-six peri-menopausal women with severe depression were treated with nilestriol, fluoxetine, Jieyu decoction and psychotherapy. All patients were evaluated by HAMD, SDS score before and af- ter treatment. Serum E2,FSH were tested at the same time. Results After 8 weeks of comprehensive rehabilitation therapy, serum E2 levels significantly increased, serum FSH levels significantly decreased. HAMD scores and SDS scores were decreased significantly （ P 〈 0. 01 ）. The results showed that 61.5 % （16/26） of patients were cured, the excellent rate and effective rate were 23.1% （6/26） and 15.4% （4/26） respectively. Condusion It is suggested that comprehensive rehabilitation therapy is a safe and effective therapeutic method with less side effect in treating peir-menopausal women with severe depression.