PPAR-γ在呼吸系统慢性疾病中的研究进展

Study progress on PPAR-γ in chronic respiratory diseases

过氧化物酶体增殖物激活受体亚型(PPAR-γ)是调节目标基因表达的核内受体转录因子超家族成员,参与调节代谢、细胞的增殖、分化和凋亡,在免疫系统中发挥着重要作用,与多种代谢性疾病和免疫性疾病的发生发展密切相关。近年来,随着对PPAR-γ研究的逐步深入,发现PPAR-γ在呼吸系统慢性疾病,如哮喘、慢性阻塞性肺病(COPD)、肺癌和肺纤维化的发病过程中起着重要的作用,PPAR-γ激动剂的应用有望成为治疗呼吸系统慢性疾病的一个新方法。

Peroxisome proliferator-activated receptor-γ （PPAR-γ）, a member of the superfamily of intrarmclear receptor transcription factor that regulating the gene expression, involves in the regulation of metabolism, cellular proliferation, differentiation and apoptosis. Its crucial role in immune system determines the close association with the occurring and development of metabolic diseases and immunological diseases. Recently, further studies have demon- strated that PPAR-γ is critical in the pathogenesis of chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease （COPD） ,lung cancer and pulmonary fibrosis et al. And PPAR-γ agonist might hopefully be a newtherapy to chronic respiratory diseases.