药物联合高压氧治疗新生儿缺氧缺血性脑病的临床研究

The Effect of Drugs Combined with Hyperbaric Oxygen in Treatment of Neonatal Hypoxic Ischemic Encephalopathy

目的探讨药物联合高压氧治疗新生儿缺氧缺血性脑病(HIE)的方法和疗效。方法回顾性分析我院收治的120例患者,平均分为两组,对照组行常规药物治疗,实验组加行高压氧治疗。随访1～2个月,观察两组患者的临床疗效,症状消失时间和不良反应。结果两组相比,实验组患者的症状消失时间少于对照组(P<0.05),轻度HIE间疗效不显著(P>0.05),但中重度HIE间疗效有差异(P<0.05),实验组总有效率高于对照组(P<0.05),而其不良反应发生率低于对照组(P<0.05)。结论药物联合高压氧治疗新生儿缺氧缺血性脑病,可显著提高疗效,减少临床症状消失时间,明显降低不良反应。

Objective To investigate the effect of drug combination high-pressure oxygen in treatment of neonatal hypoxic ischemic encephalbpathy. Methods One hundred and twenty patients were divided into two groups with 60cases in each , control group underwent conventional drug treatment, the experimental group received hyperbaric oxygen therapy. 1 to 2 month follow-up, patients were observed in clinical efficacy, time, and symptoms of adverse reactions. Results During follow-up between the two groups compared to the experimental group after treatment of patients with symptoms for less than the control group （P 〈 0.05 ）, there was no significant effect （ P 〈 0.05 ）, but the efficacy of moderate to severe HIE there are differences （ P 〈 0.05 ）, total efficiency of the experimental group was higher （ P 〈 0.05 ）, while the incidence of adverse reactions than the control group （P 〈 0.05 ）. Conclusion The drug combination of hyperbaric oxygen treatment of neonatal hypoxic ischemic encephalopathy, can significantly improve efficacy and reduce the time of clinical symptoms, significantly reduced side effects.