2型糖尿病视网膜病变患者血脂水平的变化及其临床意义

The Changes and Its Singnificance of Lipid Level in Patients with Diabetic Retinopathy

目的探讨2型糖尿病(T2DM)视网膜病变患者血脂水平的变化及其临床意义。方法 101例T2DM患者和30例健康查体者(对照组)为研究对象,T2DM患者分为无视网膜病变组(NDR组)、背景型视网膜病变组(BDR组)、增殖型视网膜病变组(PDR组)。测定各组的血脂水平。结果 T2DM组TC、TG、LDL-C水平高于对照组,HDL-C显著低于对照组,相比较有显著性差异(P<0.05);病变组TC、TG、LDL-C水平高于NDR组,HDL-C显著低于NDR组,相比较有显著性差异(P<0.05);PDR组TC、TG、LDL-C水平高于BDR组,HDL-C显著低于BDR组,相比较有显著性差异(P<0.05);糖尿病视网膜病变程度与TC、TG、LDL-C水平呈显著正相关(r=0.514,0.581,0.517;P<0.01),与HDL-C水平呈显著负相关(r=-0.551,P<0.05)。结论血脂水平在T2DM视网膜病变进程中起着非常重要的作用,血脂水平可以做为判定T2DM发生DR的指标。

Objective To investigate the changes and its clinical significance of lipid level in patients with diabetic retinopathy. Methods All 101 cases of type 2 diabetes mellitus （ T2DM ） patients with diabetic and 30 cases of healthy people （ control group ） were used as objects of study. T2DM patients were divided into three groups： NDR group, BDR group and PDR group. The lipid level was detected. Results The TC, TG and LDL-C level of the T2DM group were significantly higher than control group, and the HDL-C level was significantly lower than control group, the difference was significant （ P 〈 0.05 ） ; The TC, TG and LDL-C level of the PDR group were significantly higher than BDR group, and the HDL-C level was significantly lower than BDR group, the difference was significant （ P 〈 0.05 ） ; The degree of DR disease was positively correlated with the TC, TG and LDL-C level （ r=0.514,0.581,0.517, P 〈 0.05 ） and negatively correlated with the HDL-C level （r=-0.551, P 〈 0.05 ）. Conclusion The lipid level plays an important role in the process of DR, the lipid level could be used an index to judge the occurrence of T2DM complicated with DR.