长托宁和阿托品联合治疗急性有机磷农药中毒的临床研究

Penehyclidine Hydrochloride Combined with Atropine in the Patients with Acute Organophosphorus Pesticide Poisoning:A Clinical Observation

目的探讨长托宁和阿托品联合使用治疗急性有机磷农药中毒(AOPP)的临床效果。方法将AOPP患者123例随机分为长托宁组、阿托品组和长托宁、阿托品联合组(联合组),观察三组的阿托品化时间、中毒症状消失时间、CHE时间、平均住院时间、治愈率及不良反应发生情况。结果联合组阿托品化时间、中毒症状消失时间、CHE时间、平均住院时间与其他两组比较均明显较短,治愈率与阿托品组比较明显较高;阿托品组心动过速发生率与其他两组比较明显增高(P<0.05)。结论长托宁和阿托品联合使用治疗AOPP的临床效果较好,起效快、用量少、不良反应少,可在临床推广应用。

Objective To explore the clinical effect of penehyclidine hydroehloride combined with atropine in the patients with acute organophosphorus pesticide poisoning （ AOPP ）. Methods One hundred and twenty-three cases of patients with AOPP were divided into penehyclidine hydrochloride group, atropine group, combination group. Observed the atropinization time, poisoning symptoms losing time, CHE time, the median length of hospital stay, the cure rate and adverse effect condition. Results The atropinization time, poisoning symptoms losing time, CHE time, the median length of hospital stay in the combination group were shorter than those in the other two groups, the cure rate was higher than that in the atropine group, tachycardia rate in the atropine group was higher than that in the other two groups, the difference was statistically significant （P 〈 0.05 ）. Conclusion The effect of penehyclidine hydrochloride combined with atropine in the patients with acute organophosphorus pesticide poisoning is satisfactory, it has a rapid onset and less used amount and fewer side effects, it is worth to beintroduced.