凝血酶原时间测定标准化在临床抗凝治疗和肝病中应用价值研究

Application Value of Prothrombin Time Measurement Standardization in Clinical Anticoagulant Therapy and Liver Disease Research

目的探讨凝血酶原测定标准化在临床中的意义及其在抗凝治疗和肝病中的应用价值。方法收集我院24例行人工机械瓣膜替换术患者,观察PT值在不同凝血活酶试剂中的变化;另24例由我院肝病科确诊为肝硬化的患者,观察在两种不同的凝血活酶试剂的PT时间和INR值。结果抗凝治疗组示对照组及术前患者用两种不同的凝血活酶所得PT值无差异,而术后口服抗凝剂治疗后,用两种不同凝血活酶所测PT值有差异;肝硬化组示两种不同试剂测出的INR值相近。结论凝血酶原测定标准化在临床抗凝治疗和肝病治疗的临床应用广泛。

Objective To study the the application value of prothrombin determination in the standardization of clinical significance and anticoagulant therapy and liver disease. Methods All 24 routine patients with artificial mechanical valve replacement in our hospital were selected, the changes of PT values was observed in different thromboplastin reagents; 24 cases in our hospital were diagnosed with cirrhosis of the liver, PT time and INR in two different blood coagulation live were observed. Results Anticoagulant therapy group showed the control group and preoperative patients using two different thromboplastin no difference in PT value obtained, and after oral anticoagulant therapy, using two different thromboplastin PT value measured differences; Cirrhosis showed two different reagents the INR values measured close. Conclusion Prothrombin determination in clinical anticoagulants standardization and the treatment of liver diseases are widely used in clinical.