摘要
目的探讨CyclinE、p27、p53在皮肤鳞状细胞癌中的表达及相关性。方法采用免疫组化法检测36例皮肤鳞状细胞癌组织中CyclinE、p27、p53,分析三者表达与皮肤鳞状细胞癌分化程度之间的关系及三者之间的相关性。结果 CyclinE、p53在皮肤鳞状细胞癌中表达均显著高于正常皮肤,随肿瘤分化程度降低而增强(P<0.05);p27在皮肤鳞状细胞癌中表达均显著低于正常皮肤,随肿瘤分化程度降低而减弱(P<0.05);CyclinE表达与p53表达呈正相关,与p27表达呈负相关。结论 CyclinE、p53在皮肤鳞状细胞癌中的表达上调,p27表达下调,三者与皮肤鳞状细胞癌分化程度存在相关性。
Objective To investigate the expression and correlation of CyclinE, p27 and p53 in squamous cell carcinoma. Methods Detected the CyclinE, p27 and p53 in 36 cases of squamous cell carcinoma, analysis the expression of these three, the relationship between these three and the degree of differentiation of tumor, the correlation among these three. Results The expression of CyclinE and p53 were higher and the normal skin, and with the decrease of the differentiation were increased （ P 〈 0.05 ） ; The expression of p27 was lower than the normal skin, and with the decrease of the differentiation were decreased （ P 〈 0.05 ） ; CyclinE and p53 had positive correlation, CyclinE and p27 had negative correlation. Conclusion The expression of CyclinE and p53 were up regulated, but expression of p27 was down regulated in the squamous cell carcinoma. They all have correlation with the degree of differentiation of tumor.
出处
《中国现代医生》
2011年第28期112-113,153,共3页
China Modern Doctor
