复方甘草酸苷对抗结核药物性肝损害的疗效观察

Clinical Effects of Compound Glycyrrhizin on Liver Injury Due to Anti-tuberculosis Drugs

目的探讨复方甘草酸苷治疗抗结核药物性肝损害的效果。方法 93例抗结核药物性肝损害患者随机分为治疗组和对照组,对照组使用维生素C、门冬酸钾镁、肝泰乐等保护性药物进行常规治疗,治疗组在此基础用药上加用复方甘草酸苷治疗。治疗前后分别观察患者症状和体征、肝功能。结果复方甘草酸苷治疗后,患者的临床症状、肝功能均有明显改善。治疗组与对照组比较总有效率分别为93.6%和69.5%,有显著性差异(P<0.01)。结论复方甘草酸苷治疗抗结核药物所致的肝损害有显著疗效。

Objective To explore the effects of compound glycyrrhizin on liver injury due to anti-tuberculosis drugs. Methods Ninty-three cases with liver injury due to anti-tuberculosis drugs were randomly divided into treatment group and control group. Patients in control group were treated with liver protective drugs such as vitamin C, Potassium Magnesium Asparate, Gantaile, etc; While cases in treatment group received compound glycyrrhizin .Clinical symptoms, biochemical indexes such as liver function and side effects were observed and compared before and after treatment. Results Clinical symptoms, liver function of the sick both had remarkable improvement after treatment. Effective rate was 93.6% in treatment group and control group effective rate was 69.5%, there was significant difference between two group （P 〈 0.01 ）. Conclusion Compound glycyrrhizin has remarkable effect on liver injury due to anti-tuberculosis drugs.