序贯疗法与10d四联疗法抗Hp疗效对比分析

Comparative analysis of anti-Hp effects of sequential therapy and 10 days quadruple therapy

目的:比较10d序贯疗法和10d四联疗法根除Hp疗效和患者依从性,进一步探讨序贯疗法的机制。方法:将经胃镜检查确诊为慢性胃炎和消化性溃疡且Hp检测(尿素酶试验)阳性的患者170例随机分为A组和B组各85例,A组采用前5d奥美拉唑+阿莫西林、后5d奥美拉唑+克拉霉素+替硝唑序贯疗法;B组采用奥美拉唑+阿莫西林+克拉霉素+替硝唑四联疗法,疗程10d,观察Hp根除情况和患者的依从性。结果:Hp根治率A组明显优于B组(P<0.05),且A组依从性优于B组。结论:在疗程和药物选择相同的情况下,序贯疗法明显优于10d四联疗法。

Objective：To compare the Hp eradication effects and patient compliance of sequential therapy and 10 days quadruple therapy and to further explore the mechanism of sequential therapy.Methods：170 patients diagnosed with chronic gastritis and peptic ulcer by endoscopy and tested positive by Hp test（urease test） were randomly divided into A group and B group with 85 patients for each group.A group received the sequential therapy of omeprazole and amoxicillin for the first 5 days and omeprazole,clarithromycin and tinidazole for the rest 5 days.B group received the 10 days quadruple therapy of omeprazole,amoxicillin,clarithromycin and tinidazole.The Hp eradication situation and patient compliance were observed.Results：A group was significantly higher than B group in the Hp eradication rate（P〈0.05）,and patient compliance of A group was higher than that of B group.Conclusion：Under the same treatment course and drug selection,the sequential therapy is significantly better than the 10 days quadruple therapy.