摘要
目的:探讨FOLFOX7与FOLFOX6两种化疗方案治疗胃癌的效果。方法:将80例胃癌患者随机分成FOL-FOX6治疗组和FOLFOX7治疗组,每组各40例,观察两组的临床疗效及不良反应。结果:FOLFOX6治疗组中CR6例,PR14例,SD14例,PD6例,总有效率为50.0%(20/40);临床获益率为87.5%(35/40),主要表现为骨髓毒性等不良反应。FOLFOX7治疗组中CR9例,PR16例,SD14例,PD1例,总有效率为62.5%(25/40);临床获益率97.5%(39/40);主要表现为骨髓毒性等不良反应。结论:FOLFOX7比FOLFOX6化疗方案的毒性反应小,有效率高,剂量合理,耐受性更好等特点,现多采用FOLFOX7治疗胃癌,提高患者生存率。
Objective：To investigate effection of the FOLFOX7 and FOLFOX6 chemotherapy in patients with gastric cancer.Methods：80 patients with gastric cancer were randomly divided into FOLFOX7 and FOLFOX6 treatment group,40 patients for each group,to observed the clinical efficacy and adverse reactions in the two groups.Results：FOLFOX6 treatment group CR 6 cases,PR 14 cases,SD 14 cases,PD 6 cases,total effective rate was 50.0%（20/40）;Clinical benefit rate was 87.5%（35/40）,mainly as bone marrow toxicity and other adverse reactions.FOLFOX7 treatment group CR 9 cases,PR 16 cases,SD 14 cases,PD 1 cases,the total effective rate was 62.5%（25/40）;Clinical benefit rate of 97.5%（39/40）;mainly bone marrow toxicity adverse reactions.Conclusion：FOLFOX7 compare with FOLFOX6 have regimens small,high efficiency,reasonable doses,tolerance and better features and so on,so FOLFOX7 be widely used for treatment of gastric cancer and improve survival rate.
出处
《中国当代医药》
2011年第27期36-37,共2页
China Modern Medicine
