胶原蛋白多肽-铬(Ⅲ)螯合物制备及功效研究

Study on the Preparation and Efficacy of Collagen Peptide-Chromium(Ⅲ) Complex

利用新鲜猪皮制备胶原蛋白多肽-铬(Ⅲ)螯合物,并测定胶原蛋白多肽-铬(Ⅲ)螯合物对试验小鼠生长发育、血糖和肝脏的影响作用,试验结果表明,胶原蛋白多肽-铬(Ⅲ)螯合物对试验小鼠的生长发育具有一定的促进作用;能够显著改善肝损伤小鼠的糖代谢功能,降低由四氧嘧啶引起的小鼠血糖升高;可以改善小鼠肝脏指数,抑制肝脏内SOD,GSH-Px等酶活力代偿性升高,有效抑制四氧嘧啶致小鼠肝脏自由基浓度的升高,减轻四氧嘧啶对肝脏细胞造成的损伤,对小鼠肝脏具有一定的保护作用。

Collagen peptide-chromium（Ⅲ） complex is prepared by fresh pig skin,and the impacts of collagen peptide-chromium（Ⅲ） on the growth and development of the mice,blood glucose and liver function are measured in this study.The result indicates that,the growth and development of the mice is promoted;glucose metabolism of the mice with liver injury is significantly improved;the hyperglycemia induced by alloxan in the mice is relieved;the liver index of the mice is improved,the increase of the activity compensatory of liver SOD,GSH-Px and other enzymes and alloxan-induced liver radical concentration is inhabited,and the damage of alloxan on the liver cells of the mice is relieved,with the protection for the liver of the mice.