低分子肝素钙治疗早发型重度子痫前期临床疗效观察

Observation on the clinical curative effect of low molecular weight heparin calcium in treatment of early onset severe preeclampsia

目的:观察低分子肝素钙治疗早发型重度子痫前期对母体的影响。方法:选取孕龄26～34周重度子痫前期患者60例,随机分为观察组和对照组,观察组在常规治疗基础上加用低分子肝素钙,对比两组血压、血脂、24 h尿蛋白定量、凝血纤溶功能、并发症的差异。结果:观察组平均动脉压、24 h尿蛋白、血脂TG、TC、LDL、apo-B均下降,HDL、apo-A增加,两组间差异有统计学意义(P<0.05);凝血功能无改变,纤溶活性降低,产后出血无增加,并发症降低。结论:抗凝治疗早发型重度子痫前期是有效安全的,低分子肝素钙可作为基本治疗药物之一。

Objective：To observe the effect of low molecular weight heparin calcium on the pregnant women in treatment of early onset severe preeclampsia. Methods：60 patients of 26~34 gestational weeks with severe preeclampsia were selected and divided into observation group and control group randomly.The patients in observation group were treated with additional low molecular weight heparin calcium on the basis of conventional treatment.The differences of indexes including blood pressure,blood lipids,24-hour urinary protein count,coagulation and fibrinolytic function,complications in the two groups were compared. Results：In observation group,the mean arterial pressure（MAP）,24-hour urinary protein count,TG,TC,LDL and apo-B decreased,HDL and apo-A increased,there was significant difference between the two groups（P0.05）;coagulation function didn＇t change,the fibrinolytic activity decreased,the amount of postpartum hemorrhage didn＇t increase,the incidences of complications decreased. Conclusion：Anticoagulant therapy is effective and safe in treatment of early onset severe preeclampsia,low molecular weight heparin calcium can be used as one of the basic drugs.