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CIP2A在膀胱尿路上皮癌中的表达及其临床意义 被引量:3

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摘要 目的:探讨膀胱尿路上皮癌(UCCB)组织中CIP2A的表达及其在膀胱尿路上皮癌发生发展中的意义。方法:应用免疫组化法及逆转录聚合酶链反应法,对48例临床分期为Tis^T1期的膀胱癌组织标本中CIP2A的表达进行检测。病理分级G1级23例,G2级17例,G3级8例;复发性膀胱癌17例;15例非肿瘤膀胱组织作对照应。结果:15例非肿瘤膀胱组织CIP2A表达均为阴性;48例膀胱癌组织中有19例可见CIP2A表达;复发的膀胱癌组织中CIP2A阳性表达率(58.82%,10/17)明显高于初发的膀胱癌组织(29.03%,9/31),两组CIP2A表达阳性率有显著性差异(P<0.05);CIP2A表达率在不同分级的肿瘤组织中无明显差异(P>0.05)。两年随访发现:CIP2A表达阳性的肿瘤病人复发率高(13/19,68.42%),与CIP2A表达阴性者的复发率(11/29,37.93%)相比有显著性差异(P<0.05)。结论:CIP2A与膀胱癌复发有关,检测膀胱癌组织中CIP2A表达有望作为膀胱癌诊断的一种指标,在膀胱肿瘤的预后判断中起重要作用。
出处 《陕西医学杂志》 CAS 2011年第9期1221-1223,1245,共4页 Shaanxi Medical Journal
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参考文献13

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同被引文献43

  • 1顾海风,夏国伟.CIP2A在恶性肿瘤中的表达及作用的研究进展[J].中华临床医师杂志(电子版),2011,5(12):3560-3563. 被引量:8
  • 2顾沈阳,俞俊杰,刘亚东,王业华,杜拥军.全自动图像细胞法、荧光原位杂交法、流式细胞仪对膀胱肿瘤的诊断和意义[J].实用癌症杂志,2014,29(1):41-44. 被引量:3
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