河南产尾叶香茶菜叶部位化学成分的分离与纯化

Seperation and purification of chemical constituents from leaves of Rabdosia excisa in Henan

目的:分离纯化河南产尾叶香茶菜(Rabdosia excisa)叶部位的化学成分。方法:利用硅胶柱色谱法对尾叶香茶菜叶部位的化学成分进行分离和纯化,通过理化性质和波谱数据鉴定结构。结果:从尾叶香茶菜叶中分离鉴定了10个化合物:1α,6,11β,15β-四乙酰基-6,7-断裂-7,20-内酯-对映-贝壳杉-16-烯(Ⅰ)、2α-羟基齐墩果酸(Ⅱ)、2α,3α,19-三羟基-12-烯-28-乌索酸(Ⅲ)、hyptadienic acid(Ⅳ)、6β,11α,15α-三羟基-6,7断裂-6,20-环氧2-1α,7-内酯-对映-贝壳杉-16-烯(Ⅴ)、α-香树脂醇棕榈酸酯(Ⅵ)、2α,3α-二羟基乌苏-12-烯-28-酸(Ⅶ)、maoyecrystal E(Ⅷ)、enmenol-glucoside(Ⅸ)及冬凌草甲素(Ⅹ)。结论:除化合物Ⅹ外,其余化合物均为首次从尾叶香茶菜中发现。

Aim： To separate and purify the constituents from leaves of Rabdosia excisa in Henan.Methods：Compounds were separated and purified by silica gel column chromatography and their structures were determined by spectroscopic method.Results：Ten compounds isolated from the leaves of this plant were identified as： rabdosinate（Ⅰ）,maslinic acid（Ⅱ） ,2α,3α,19-trihydroxy-urs-12-en-28-oic acid（Ⅲ）,hyptadienic acid（Ⅳ）,6β,11α,15α-trihydroxy-6,7-seco-6,20-epoxy-1 α,7-olide-ent-kaur-16-en,epinodosinol（Ⅴ）,α-amyrin palmitate（Ⅵ）,2α,3α-dihydroxy-urs-12-en-28-oic acid（Ⅶ）,maoyecrystal E（Ⅷ）,enmenol-glucoside（Ⅸ）,and oridonol （Ⅹ）.Conclusion：All the constituents are found in leaves of Rabdosia excisa for the first time,except constituent Ⅹ.