彻底消毒前后神经内科病房病原菌构成及耐药性检测

Changes of pathogens distribution and antibiotic resistance in neurology ward after thorough disinfection

目的:观察神经内科病房彻底消毒前后病原菌构成与耐药性的变化,为院内感染的防治提供理论依据。方法:对神经内科病房进行彻底消毒并空闲至少3个月后,只收新患者,并严格按照院内感染防治方法进行管理,标本按常规方法留取,送检。采用法国梅里埃VITEK2-compact自动微生物鉴定仪进行菌株鉴定与药敏测定。结果:消毒后病原菌检出数量由484株减少为219株,菌株来源、病原菌构成有很大变化(χ2=18.140、92.270,P均<0.05),临床分离的病原菌仍以革兰阴性杆菌为主。消毒后耐药分布也发生了较大改变。结论:全面、彻底消毒是减少院内感染的有效措施,但抗生素的选择仍面临巨大挑战。

Aim：To analyze the pathogen distribution and antibiotic resistance in neurology ward.Methods：The neurology ward was thoroughly disinfected and idled for at least 3 months before accepting the first patient,and was in strict accordance with the management of nosocomial infection control methods.The pathogens from specimens were isolated and cultivated,as well as identified and classified with VITEK2-compact automatic system.Results：The number of pathogen reduced from 484 to 219 after disinfection,the source and distribution of pathogen changed significantly（χ^2=18.140,92.270,P〈0.05）.Gram-negative bacilli were the most common bacteria.Conclusion：A thorough disinfection is an effective measure to reduce nosocomial infections,however,the choice of antibiotics is still facing great challenges.