5，10-亚甲基四氢叶酸还原酶C677T基因多态性与急性淋巴细胞白血病易感性关系的Meta分析

Study on the association between 5, 10-methylenetrahydrofolate reductase C677T polymorphismand acute lymphoblastic leukemia risk： a Meta-analysis

目的运用Meta分析的方法综合评价5，10-亚甲基四氢叶酸还原酶（MTHFR）基因C677T多态性与急性淋巴细胞白血病（ALL）的相关性。方法制定原始文献的纳入和排除标准及检索策略。检索中外文数据库，收集有关MTHFR基因C677T多态性与ALL相关性的研究报告，采用TT／CC＋CT以及TT／CC基因型比较模型进行定量综合分析，然后按年龄（儿童或成年人）分亚组进行分析。结果综合分析显示，MTHFR基因677位点TT／CC＋CT、TT／CC模型计算OR值（95％CI）分别为O．87（0．69～1．09）、0．82（0．63～1．06）；在儿童组TT／CC^CT、TT／CC模型计算OR值（95％CI）分别为0．92（0．79～1．08）、0．88（0．75～1．05），在成年人组TT／CC＋CT、TT／CC模型计算OR值（95％C1）分别为0．45（0．26～0．77）、0．41（0．22～0．72）。结论MTHFR基因C677T突变与儿童ALL无关联，但可能减弱成年人ALL发生的危险。

Objective To evaluate the association between polymorphism of 5, 10-methylenetrahydrofolate reductase C677T and risk of acute lymphoblastic leukemia （ALL）. Methods Electronic search strategy was carried out among the databases from home and abroad to collect qualified research papers, according to the inclusion and exclusion criteria. Data on case-control studies on association between MTHFR C677T polymorphism and susceptibility to ALL were colleted and analyzed by models of TT vs. CC ＋ CT or TT vs. CC through Meta-analysis. Stratified analysis was carried out according to different age groups （children or adult）. Results In systematical analysis, the pooled odds ratios of MTHFR C677T genetype TT vs. CC ＋ CT or TT vs. CC were 0.87 （0.69-1.09） and 0.82 （0.63-1.06） respectively; in children＇s group, the pooled odds ratios of MTHFR C677T genetype TT vs. CC＋CT or TT vs. CC were 0.92（0.79-1.08） ,0.88（0.75-1.05） while in adult group, the pooled odds ratios of MTHFR C677T genetype TT vs. CC ＋ CT or TT vs. CC were 0.45 （0.26-0.77）, and 0.41 （0.22-0.72） respectively. Conclusion The MTHFR gene 677T variant might not be associated with the risk of children＇s ALL but might be associated with a reduced risk on adult＇ s ALL.