颅内静脉窦血栓形成后昏迷患者预后相关因素研究

Prognostic factors in coma patients with intracranial venous sinus thrombosis

目的探讨影响颅内静脉窦血栓形成（CVST）后昏迷患者预后的相关因素。方法对梧州市工人医院神经内科自2001年2月至2010年2月收治的以昏迷就诊或在人院6h内出现不同程度昏迷的30例CVST患者的临床资料进行回顾性分析。结果随访0．5-10年，本组患者中12例无明显颅内压增高、脑深静脉血栓及相关脑血管意外，8例死亡，2例重残，8例遗留不同程度的偏瘫或智力语言障碍。CVST后昏迷患者伴有中枢神经系统感染、恶性肿瘤、脑深静脉血栓形成、癫痫及颅内出血等改变时患者预后差，其中恶性肿瘤患者重残或死亡率高达50％。结论CVST后发生昏迷的患者预后差，病死率高，及早诊治并合理治疗有助于改善预后。

Objective To investigate the factors affecting the prognosis of coma patients with cerebral venous sinus thrombosis （CVST）. Methods We retrospectively analyzed the clinical data of 30 coma patients with CVST, admitted to our hospital from February 2001 to February 2010, including patients in coma on admission and patients turned to be in the different degrees＇ coma after admission within 6 h. Results Twelve patients had no increased intracranial pressure, cerebral venous sinus thrombosis or related symptoms with cerebral vascular; 8 patients died and 2 were seriously disable; 8 suffered from sequel of different degrees of hemiplegia or mental language barriers. The CVST patients associated with infection in central nervous system, cancer, cerebral deep venous thrombosis, epilepsy and intracranial hemorrhage were with poor prognosis, enjoying a possibility of mortality and severe disability up to 50%. Conclusion Coma patients with CVST were with poor prognosis and high mortality; early diagnosis and appropriate treatment might help to improve the prognosis.