期刊文献+

首发未服药精神分裂症患者脑弥散张量成像的基于体素分析 被引量:6

A voxel-based diffusion tensor imaging study of first-episode medication-free patients with schizophrenia
原文传递
导出
摘要 目的分析首发未服药精神分裂症患者脑白质完整性的变化。方法对40例首发未服药精神分裂症患者和68例健康对照者进行脑弥散张量磁共振成像检查,以DTI-studio软件和统计参数图(SPM)软件对所得图像进行预处理,得到的各向异性分数(FA)图像在SPM软件中进行两样本t检验.获得两组患者FA值差异统计参数图。结果在P值小于0.001(未校正)水平下。首发未服药精神分裂症患者右侧杏仁核区(MNI:24,2,-14,cluster=347voxels)、双侧前扣带区(MNI:6,42,2,cluster=586voxels)、右侧前额叶眶上回区域(MNI:20,18,-10,cluster=166voxels)白质FA值较健康对照者下降,且未发现前者有脑区白质FA值较后者增高。结论精神分裂症患者皮层一边缘系统环路存在结构连接障碍,这可能是精神分裂症的神经机制。 Objective To explore the changes of white matter integrity in first-episode medication-free patients with schizophrenia. Methods Diffusion tensor images (DTI) of whole brains of 40 first-episode medication-free patients with schizophrenia and 68 healthy controls were acquired with a single-shot echo planar imaging (EPI) sequence aligned to the straight axial plane. Two-sample t-test by with voxel-based analysis in SPM5 sottware was performed on the fractional anisotropy (FA) images of the 2 groups after being preprocessed with DTI-studio and SPM5 software. Results Subjects of schizophrenia showed reduced white matter FA in these regions: the right amygdale (MNI: 24, 2, -14; cluster=347 voxels), bilateral anterior cingulate (MNI: 6, 42, 2; cluster=586 voxels), right orbitofrontal (MNI: 20, 18, -10; cluster=166 voxels) as compared with healthy controls. Conclusion Abnormal white matter in the corticolimbic system circuit exists in patients with schizophrenia, which maybe involve in the neural mechanism of schizophrenia.
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2011年第9期926-928,共3页 Chinese Journal of Neuromedicine
基金 基金项目:2010年卫生行业科研专项(201002003) 国家自然科学基金青年项目(30900485) 广东省自然科学基金(9151008901000065)
关键词 精神分裂症 白质 弥散张量成像 基于体素分析 Schizophrenia White matter Diffusion tensor imaging Voxel-based analysis
  • 相关文献

参考文献8

  • 1Pettersson-Yeo W, Allen P, Benetti S, et al. Dysconnectivity in schizophrenia: Where are we now?[J]. Neurosci Biobehav Rev, 2011,35(5): 1110-1124.
  • 2魏钦令,朱康顺,王相兰,张晋碚,康庄,国效峰,韩自力,赵靖平.精神病未治疗期对首发未服药精神分裂症脑白质完整性的影响[J].中华神经医学杂志,2010,9(11):1125-1128. 被引量:6
  • 3Konrad A, Winterer G. Disturbed structural connectivity in schizophrenia primary factor in pathology or epiphenomenon? [J]. Schizophr Bull, 2008, 34(1): 72-92.
  • 4魏钦令,康庄,王相兰,张晋碚,李雷俊,郑俩荣,韩自力.首发未服药偏执型分裂症脑白质的弥散张量成像研究[J].中华行为医学与脑科学杂志,2010,19(9):784-786. 被引量:8
  • 5Belforte JE, Zsiros V, Sklar ER, et al. Postnatal NMDA receptor ablation in corticolimbic intemeurons confers schizophrenia-like phenotypes[J]. Nat Neurosci, 2010, 13(1): 76-83.
  • 6Benes FM. Amygdalocortical circuitry in schizophrenia: from circuits to molecules[J]. Neuropsychopharmacology, 2010, 35(1): 239-257.
  • 7Pessoa L, Adolphs R. Emotion processing and the amygdala: from a 'low road' to 'many roads' of evaluating biological significance [J]. Nat Rev Neurosci, 2010, 11(11): 773-783.
  • 8Tomasino B Bellani M, Perlini C, et al. Altered microstructure integrity of the amygdala in schizophrenia: a bimodal MRI and DWI study[J]. Psychol Med, 2011,41(2): 301-311.

二级参考文献23

  • 1Begre S,Koeing T.Cerebral Disconnectivity: an early event in schizophrenia.Neuroscientist ,2008,14:19-45.
  • 2Ellison-Wright I,Bullmore E.Meta-analysis of diffusion tensor imaging studies in schizophrenia.Schizophr Res,2009,108:3-10.
  • 3Spoletini I,Cherubini A,Banfi G,et al.Hippocampi,thalami,and accumbens microstructural damage in schizophrenia: a volumetry,diffusivity,and neuropsychological study.Schizophr Bull,2009[First published online].
  • 4Friedman JI,Tang C,Carpenter D,et al.Diffusion tensor imaging findings in first-episode and chronic schizophrenia patients.Am J Psychiatry,2008,165:1024-1032.
  • 5Navari S,Dazzan P.Do antipsychotic drugs affect brain structure?A systematic and critical review of MRI findings.Psycbol Med,2009,39:1763-1777.
  • 6Joyce EM,Roiser JP.Cognitive heterogeneity in schizophrenia.Curr Opin Psychiatry ,2007,20:268-272.
  • 7Stroup TS.Heterogeneity of treatment effects in schizophrenia.Am J Med,2007,120: S26-31.
  • 8Lake CR.Hypothesis:grandiosity and guilt cause paranoia; paranoid schizophrenia is a psychotic mood disorder:a review.Schizophr Bull,2008,34:1151 -1162.
  • 9Ramnani N,Behrens TE,Penny W,et al.New approaches for exploring anatomical and functional connectivity in the human brain.Biol Psychiatry,2004,56: 613 -619.
  • 10Rose SE,Chalk JB,Janke AL,et al.Evidence of altered prefrontal-thalamic circuitry in schizophrenia: an optimized diffusion MRI study.Neuroimage ,2006,32:16-22.

共引文献11

同被引文献92

  • 1Insel TR. Rethinking schizophrenia. Nature,2010,468 : 187-193.
  • 2Gejman PV, Sanders AR, Duan J. The role of genetics in the etiology of schizophrenia. Psychiatr Clin North Am,2010,33:35- 66.
  • 3Kaymaz N, van Os J. Heritability of structural brain traits an endophenotype approach to deconstruct schizophrenia. Int Rev Neurobiol, 2009,89 : 85 -130.
  • 4Lawrie SM, Mcintosh AM, Hall J, et al. Brain structure and function changes during the development of schizophrenia: the evidence from studies of subjects at increased genetic risk. Schizophr Bull,2008,34 : 330 -340.
  • 5Pettersson-Yeo W, Alien P, Benetti S, et al. Dysconnectivity in schizophrenia : where are we now? Neurosci Biobehav Rev, 2011, 35:1110-1124.
  • 6Munoz MS, Lymer GK, Bastin ME, et al. A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia. Schizophr Res ,2008,106 : 132-139.
  • 7Hoptman M J, Nierenberg J, Bertisch HC, et al. A DTI study of white matter microstructure in individuals at high genetic risk for schizophrenia. Schizophr Res ,2008,106 : 115-124.
  • 8Camcbong J, Lim KO, Sponheim SR, et al. Frontal white matter integrity as an endophenotype for schizophrenia: diffusion tensor imaging in monozygotic twins and patients' nonpsychotic relatives. Front Hum Neurosci ,2009,3:35.
  • 9Hao Y, Yan Q, Liu H, et al. Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex. Schizophr Res,2009,114 : 128-135.
  • 10Kim SN, Park JS, Jang JH, et al. Increased white matter integrity in the corpus callosum in subjects with high genetic loading for schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry,2012, 37:50-55.

引证文献6

二级引证文献22

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部