摘要
目的分析首发未服药精神分裂症患者脑白质完整性的变化。方法对40例首发未服药精神分裂症患者和68例健康对照者进行脑弥散张量磁共振成像检查,以DTI-studio软件和统计参数图(SPM)软件对所得图像进行预处理,得到的各向异性分数(FA)图像在SPM软件中进行两样本t检验.获得两组患者FA值差异统计参数图。结果在P值小于0.001(未校正)水平下。首发未服药精神分裂症患者右侧杏仁核区(MNI:24,2,-14,cluster=347voxels)、双侧前扣带区(MNI:6,42,2,cluster=586voxels)、右侧前额叶眶上回区域(MNI:20,18,-10,cluster=166voxels)白质FA值较健康对照者下降,且未发现前者有脑区白质FA值较后者增高。结论精神分裂症患者皮层一边缘系统环路存在结构连接障碍,这可能是精神分裂症的神经机制。
Objective To explore the changes of white matter integrity in first-episode medication-free patients with schizophrenia. Methods Diffusion tensor images (DTI) of whole brains of 40 first-episode medication-free patients with schizophrenia and 68 healthy controls were acquired with a single-shot echo planar imaging (EPI) sequence aligned to the straight axial plane. Two-sample t-test by with voxel-based analysis in SPM5 sottware was performed on the fractional anisotropy (FA) images of the 2 groups after being preprocessed with DTI-studio and SPM5 software. Results Subjects of schizophrenia showed reduced white matter FA in these regions: the right amygdale (MNI: 24, 2, -14; cluster=347 voxels), bilateral anterior cingulate (MNI: 6, 42, 2; cluster=586 voxels), right orbitofrontal (MNI: 20, 18, -10; cluster=166 voxels) as compared with healthy controls. Conclusion Abnormal white matter in the corticolimbic system circuit exists in patients with schizophrenia, which maybe involve in the neural mechanism of schizophrenia.
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2011年第9期926-928,共3页
Chinese Journal of Neuromedicine
基金
基金项目:2010年卫生行业科研专项(201002003)
国家自然科学基金青年项目(30900485)
广东省自然科学基金(9151008901000065)
关键词
精神分裂症
白质
弥散张量成像
基于体素分析
Schizophrenia
White matter
Diffusion tensor imaging
Voxel-based analysis