结直肠神经内分泌肿瘤的研究进展

Progress of colorectal neuroendocrine neoplasm

【摘要】结直肠神经内分泌肿瘤来源于结直肠神经内分泌细胞，发病率较低，但近年有上升趋势。WHO病理学将结直肠神经内分泌肿瘤分为神经内分泌瘤、神经内分泌癌、混合型腺一神经内分泌癌和增生性及肿瘤前病变。结直肠神经内分泌肿瘤细胞具有激素合成及分泌功能，但不一定都出现相应的临床症状。不同分类、分期的结直肠神经内分泌肿瘤的诊断及治疗方法也有所不同。

Colorectal neuroendocrine neoplasm （NEN） is originated from colorectal neuroendocrine ceils. The incidence of colorectal NEN is low, however it has been increasing in recent years. As the research work has gone further, WHO has graded colorectal NEN to neuroendocrine tumor, neuroendocrine carcinoma, mixed gland-neuroendocrine carcinoma and hyperplastic and pre-neoplastic lesions. Ahhough colorectal NEN cells can produce hormones and have endocrine functions, the clinical symptoms may not be shown. The diagnosis and treatment for colorectal NEN are different according to different classifications and stages.