侵袭性T细胞非霍奇金淋巴瘤的耐药机制

Progress of drug resistance mechanism in aggressive T cell non-Hodgkin lymphomas

侵袭性T细胞非霍奇金淋巴瘤（T—NHL）是一组高度恶性肿瘤，临床上以病情进展迅速、生存时间短为特征。这种高度恶性进程与其对化疗药物耐药，导致化疗治疗失败密切相关。因此，阐明侵袭性T-NHL的耐药机制对逆转药物耐药、改善其不良预后具有重要指导意义。

Aggressive T cell non-Hodgkin lymphomas are a group of highly malignant tumors characterized by rapid progress and short survival. This is especially true for patients who have a poor response to treatment because of their drug resistance. Hence, to clarify the mechanism of this resistance will have important guiding significance in reversing drug resistance and improving poor prognosis of aggressive T cell non- Hodgkin＇s lymphomas.