思密达联合庆大霉素加地塞米松保留灌肠治疗放射性直肠炎33例临床观察

Clinical observation on retention enema with smecta and getamycin and dexamethasone treatment for 33 cases with radioactive proctitis

目的:观察思密达联合庆大霉素加地塞米松保留灌肠治疗放射性直肠炎的疗效。方法:65例放射性肠炎随机分为两组,治疗组33例,对照组32例。两组均补液、营养对症治疗。在此基础上,治疗组给予生理盐水50 mL加思密达3.0 g加庆大霉素8万U加地塞米松5.0 m g保留灌肠,每日1次,7 d为1个疗程;对照组庆大霉素8万U加思密达3.0 g口服,每日3次,7 d为1个疗程。结果:治疗组有效率为93.9%,对照组有效率75.0%,两组对比,差异有显著性(χ2=4.48,P<0.05)。结论:思密达联合庆大霉素加地塞米松保留灌肠有很好的止泻作用,效果确切,值得推广。

Objective：To evaluate the clinical effection of retention enema with smecta and getamycin and dexamethasone on the pations with radiation proctitics.Methods：Sixty-five patients were randomly divided into two groups：thirty-three in treatment group and thirty-two in the control group.All patients in the two groups were admininistrated with liquid nourishment support.In the treatment group,50 mL normal saline,3.0 g smecta,5.0 mg dexamethasone injection,80 000 U gentamycin sulfate were given via retention enema,one times every day for one week;While in control group the patients were taken 80 000 U gentamycin sulfate and 3.0 g three times a day for one week.Results：The effective rate were 93.9% and 75.0% in treatment group and control group.Respectively there was a significant difference between two groups（χ2=4.48,P0.05）.Conclusion：Retention enema with smecta and gentamycin sulfate and dexamethasone injection for patients with adiation proctitis has good effect.It is an effective and convenient t reatment with slight side-effects for controlling radiation induced entero-colitis.So it is worthy of further study and clinical application extensively.