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microRNA在骨骼肌发育中的功能及其表达的营养调控 被引量：3

MicroRNA:Functions in Skeletal Muscle Development and Nutritional Regulations on Its Expression
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摘要 microRNA(miRNA)是真核生物中一类参与调控基因表达的非编码小分子RNA,它通过翻译抑制和使靶mRNA降解,在基因表达中起着负调控作用,与骨骼肌发育、疾病等密切相关。营养可以调控miRNA及其靶基因的表达,这将为更深层次诠释营养素的作用机理提供新的研究方向。本文综述了miRNA的结构和作用机制、骨骼肌miRNA在不同动物中的表达谱、miRNA对骨骼肌发育的调控、miRNA与骨骼肌疾病的关系和miRNA表达的营养调控的研究进展。 MicroRNAs（miRNAs）are a class of small non-coding RNA that act as regulators of gene expression in eucaryota.They negatively regulate gene expression by translational suppression and target mRNA degradation,and are closely related to skeletal muscle development and muscular diseases.Nutrition can regulate expression of miRNA and its target genes,which may bring a new research direction for mechanisms of nutrients.This paper mainly reviews research advances in structure and mechanism of miRNA,skeletal muscle miRNA expression profiling in different kinds of animals,miRNA regulation of skeletal muscle development,relationship between miRNA and skeletal diseases,as well as nutritional regulation of miRNA expression.
作者 黄志清 陈小玲 余冰 毛湘冰 陈代文
机构地区 四川农业大学动物营养研究所
出处 《动物营养学报》 CAS CSCD 北大核心 2011年第10期1647-1650,共4页 CHINESE JOURNAL OF ANIMAL NUTRITION
基金 国家自然科学基金(30972119) 四川省教育厅资助科研项目(00924800)
关键词 MICRORNA 骨骼肌发育 营养调控 microRNA skeletal muscle development nutritional regulation
分类号 S811.3 [农业科学—畜牧学]
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参考文献3

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同被引文献33

  • 1Henry V(o|¨)lzke,Daniel M.Robinson,Volker Kleine,Roland Deutscher,Wolfgang Hoffmann,Jan Lüdemann,Ulf Schminke,Christof Kessler,Ulrich John.Hepatic steatosis is associated with an increased risk of carotid atherosclerosis[J].World Journal of Gastroenterology,2005,11(12):1848-1853. 被引量：29
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动物营养学报
2011年 第10期

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