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胶滴肿瘤药敏试验检测胃癌细胞化疗敏感度 被引量：3

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摘要 0引言 化疗在胃癌综合治疗中占据重要地位。通过药敏试验选择有效的化疗药物,对指导临床用药、提高疗效、减轻不良反应具有重要意义。胶滴肿瘤药敏检测（collagen gel droplet culture drug-sensitivitytest,CD-DST）技术的原理是利用Ⅰ型胶原蛋白凝胶在37℃时能够形成三维立体结构的特点,将肿瘤细胞埋入胶原蛋白中,在近似于体内环境的条件下评定药物的敏感度。
作者 谭志军 姜伟 谷川 张建良
机构地区 天津市第一中心医院普通外科
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2011年第9期1074-1075,1092,共3页 Cancer Research on Prevention and Treatment
基金 天津市卫生局基金资助项目(07KY30)
关键词 胶滴肿瘤药敏检测 敏感测试 胃癌
分类号 R735.2 [医药卫生—肿瘤] R73-34 [医药卫生—肿瘤]
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参考文献13

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同被引文献37

  • 1梁智,张伟.胶滴肿瘤药敏检测技术的研究进展[J].癌症进展,2005,3(5):442-448. 被引量：7
  • 2张晶晶,范开席.晚期胃癌的治疗策略[J].中华临床医师杂志（电子版）,2012,6(18):132-133. 被引量：8
  • 3李玉升,张弘刚,黄镜,迟.依荷芭丽,杨林,宋岩,张雯,胡兴胜,袁芃,王金万.含有CPT-11的联合化疗方案治疗晚期胃肠道癌26例临床观察[J].临床肿瘤学杂志,2004,9(3):265-266. 被引量：15
  • 4李玉阳,刘奇.山东省乳腺疾病调查报告与乳腺癌危险因素分析[D].山东大学,2011.
  • 5Michalopoulos G, Pitot HC. Primary culture of parench- ymal liver cells on collagen membranes. Morphological and biochemical observations[J]. Exp Cell Res, 1975,94 (1):70-78.
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  • 7Kobayashi H, Tanisaka K, Doi O, et al. An in vitro chemosensitivity test for solid human tumors using col- lagen gel droplet embedded cultures[J]. Int J Oncol, 1997,11(3):449-455.
  • 8Ochiai T, Nishimura K, Watanabe T, et al. Identification of responders/non-responders to 5-fluorouracil based on individual 50% inhibitory area under the concentration curve of 5-fluorouracil obtained with collagen gel droplet-embedded culture-drug sensitivity test in col- orectal cancer[J]. Oncol Lett, 2011,2(2):309-313.
  • 9Tokunaga Y, Ohnishi T, Sasaki H. Investigation of chemotherapy based on enzyme expression and drug sensitivity test in colorectal cancer[J]. Gan To Kagaku Ryoho, 2011,38(1):69-73.
  • 10. Wang X, Zuo D, Chen Y, et al. Shed syndecan-1 is in- volved in chemotherapy resistance via the EGFR path- way in colorectal cancer[J]. Br J Cancer, 2014,111(10): 1965-1976.

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肿瘤防治研究
2011年 第9期

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