广东地区2007～2009年禽源大肠杆菌的耐药性演变

Investigation of the anti-drug resistance in Escherichia coli isolates from chickens in Guangdong between 2007 and 2009

通过对2007～2009年内从广东省10多个地市分离得到的378株禽源大肠杆菌进行15种兽医临床常用抗生素的药物敏感性试验(MIC),调查该区域禽类大肠杆菌的耐药性演变情况。采用琼脂稀释法对临床分离株开展MIC测试。结果显示临床分离株对多数兽医临床常用抗生素耐药率在30%以上,且有逐年上升的趋势,多数药物的半数抑菌浓度(MIC50)和有效抑菌浓度(MIC90)水平高且保持逐年升高的趋势;细菌的多重耐药情况严重,多集中在5～12耐,提示细菌的耐药能力逐渐提高。表明,广东地区禽源大肠杆菌的耐药水平已经达到了较为严重的程度,应加强食用动物源细菌耐药性的监测。

To investigate the anti-drug resistance in Escherichia coli isolates from chickens in Guangdong between 2007 and 2009,the susceptibility of 378 E.coli strains to 15 antimicrobial agents（MIC） was determined by agar disc dilution method.The results showed that anti-drug resistance rate of the isolates to multiple drugs was higher than 30% and keep a rising trend year by year.The multi-drug resistance is severe,and majorities of the isolates were resistant to 5-12 drugs,suggesting that antibacterial ability of these drugs are declining and the monitor of bacterium resistance from food-producing animals is necessary.