健胃愈疡胶囊联合“三联疗法”治疗幽门螺杆菌阳性老年人消化性溃疡

pylori-related peptic Effect of Jianwei yuyang capsule plus triad-therapy of western medicine on heficobacterulcer in elderly

目的探讨健胃愈疡胶囊治疗幽门螺杆菌（Hp）阳性老年人消化性溃疡的效果。方法选取80例Hp阳性，年龄在60岁以上的消化性溃疡患者，随机分为两组。治疗组给予中药健胃愈疡胶囊和“三联疗法”（奥美拉唑，阿莫西林，甲硝唑）；对照组仅给予“三联疗法”，疗程均为4周。治疗结束后6周应用胃镜和活检染色对溃疡愈合率和Hp根除率进行分析，同时观察主要症状改善情况。结果治疗组和对照组患者溃疡愈合率分别为75％（30／40）和50％（20／40），差异有统计学意义（X^2=5．33，P〈0．05）；患者Hp根除率分别为85％（34／40）和65％（26／40），差异有统计学意义（X^2=4．27，P〈0．05）；治疗有效率分别为90％和68％，差异有统计学意义（X^2=6．05，P〈0．05）。结论中药健胃愈疡胶囊联合“三联疗法”是一种比较理想的治疗Hp阳性老年消化性溃疡的治疗方案。

Objective To observe the clinical effects of Jianwei yuyang capsule combined with triad-therapyof western medicine on helicobacter pylori-related peptic ulcer in elderly. Methods Eighty patients above 60 years with peptic ulcer infected with helicobacter pylori were divided into two groups by random, and were treated with Jianweiyuyang capsule combined with triad-therapy of western medicine or triad-therapy of western medicine for 4weeks. The endoscopy and biopsy staining were used to analyze the cure rate and the helicobacter pylori eradication rate at the 6th week after the end of the treatment, and the main symptom improvement were observed. Results In the treatment group,the cure rate,the helicobacter pylori eradication rate and total effective rate were significantly higher than control group. The two groups were significantly different （ P 〈 0.05 ）. Conclusion Jianweiyuyang capsule combined with triad-therapy of western medicine was a more ideal treatment program for helicobacter pylori-related peptic ulcer in elderly.