瑞格列奈联合二甲双胍治疗2型糖尿病的疗效观察

Observation on the effect of repaglinide combined with metformin in treatment of patient with type 2 diabetes

目的探讨瑞格列奈联合二甲双胍在2型糖尿病治疗中的应用价值。方法选择2型糖尿病患者92例，随机分为观察组和对照组。两组患者均给予瑞格列奈治疗，观察组则在此基础上加用二甲双胍，并对两组患者的糖代谢和血脂以及体质量变化等临床疗效进行比较分析。结果与对照组相比，观察组治愈率和总有效率分别为58．7％和97．8％，无效率为2．2％，差异均有统计学意义（X^2=2．64，3．59，3．59，P〈0．05）；观察组空腹血糖和餐后2h血糖以及糖化血红蛋白等糖代谢指标均显著降低（P〈0．05）；观察组的三酰甘油和胆固醇等血脂指标以及体质量指数均显著降低（P〈0．05）。结论瑞格列奈联合二甲双胍对于提高2型糖尿病患者的临床疗效具有十分重要的意义。

Objective To explore the application value of repaglinide combined with metformin in type 2 diabetes therapy. Meth6ds 92 patients with type 2 diabetes were randomly divided into study group and control group. Two groups of patients were given repaglinide treatment, patients in study group given mefformiu treatment. The blood lipid, glucose metabolism, body weight change and clinical outcomes were compared belween the groups. Results Compared with the control group, study group the cure rate and total effective rate was significantly increased ,as high as 58.7% and 97.8% ,the ineffective rate was significantly decreased,only 2.2% ,there were significant differences （X^2 = 2.64,3.59,3.59, P 〈 0.05 ）. The fasting and 2h postprandial blood glucose and glycated hemoglobin and other indicators of glucose metabolism in the study group were significantly decreased, there were also significant differences （ P 〈 0.05 ）. The triglycerides and cholesterol and other lipid levels and body mass index in the study group were significantly decreased, there were significant differences （ P 〈 0.05 ）. Conclusion Repaglinide combined with metformin in type 2 diabetes treatment was remarkable for type 2 diabetes to further improve the clinical efficacy.