大蒜素联合TFP方案治疗晚期胃癌的毒副作用及对端粒酶活性的影响

Toxicity and telomerase activity of allicin combined with TFP chemotherapy for patients with advanced gastric carcinoma

目的观察大蒜素联合TFP（紫杉醇＋5-氟尿嘧啶＋顺铂）方案治疗晚期胃癌患者的疗效和不良反应发生情况，以及对端粒酶活性的影响。方法采用TFP方案治疗54例晚期胃癌患者，随机分成2组：A组27例，在化疗的同时加用大蒜素治疗；B组27例，单纯化疗。化疗方案为紫杉醇135mg／m^2第1、8天，5-氟尿嘧啶500mg／mz第1天至第5天，顺铂75mg／133z第2天至第4天，大蒜素肠溶胶囊共服用60d（20mg／次，3次／d，口服）。应用酶联免疫法检测端粒酶的活性。结果A组患者有效率为40．7％（11／27），B组有效率为33．3％（9／27），差异无统计学意义（χ2=0．079，P=0．779）。A组恶心、呕吐胃肠道不良反应发生率为77．8％（21／27），较B组的92．6％（25／27）低，差异有统计学意义（P=0．043）。A、B两组治疗后血清端粒酶浓度差异有统计学意义（P=0．000）。结论大蒜素能够减轻化疗的不良反应，同时具有抑制端粒酶活性的作用。

Objective Observe the efficacy, toxicity and the effection of telomerase activity of allicin combined with paclitaxel plus cisplatin and 5-Fu （TFP） chemotherapy for patients with advanced gastric carcinoma. Methods Fifty-four patients with advanced gastric carcinoma were randomly divided into two groups. A group was treated with allicin and TFP, B group was only treated with TFP. The chemotherapy was paclitaxel （135 mg/m2, dl, 8） plus cisplatin （75 mg/m2, d2-4） followed by 5-Fu （500 mg/m2 dl-5）. Allicin was used in 60 days （3 times every day, once 20 mg）. Telomerase activity was performed by enzyme-linked immunosorbent assay. Results The total efficiency rate was 40.7 % （11/27） in A group and 33.3 % （9/27） in B group. There was no statistical difference between the two groups 0（2 = 0.079, P =0.779）. There was significant difference in nausea and vomit （P =0.043）, and the incidence of A group was 77.8 % （21/27） which was lower than that of B group [92.6 % （25/27）]. There was statistical difference in telomerase activity between the two groups （P =0.000）. Conclusion Allicin could reduce the toxicity of chemotherapy and inhibit the telomerase activity in advanced gastric carcinoma.