摘要
目的:探讨膜联蛋白Ⅰ(AnnexinⅠ)在多囊卵巢综合征(PCOS)大鼠卵泡颗粒细胞的表达及生物学意义。方法:采用免疫组织化学方法及灰度值测定AnnexinⅠ在PCOS组和对照组的卵泡颗粒细胞中的表达。结果:AnnexinⅠ在两组中的各级卵泡颗粒细胞中均有表达,PCOS组AnnexinⅠ在窦状卵泡中表达显著高于对照组(P<0.05)。结论:PCOS组AnnexinⅠ在窦状卵泡颗粒细胞的表达上调,且PCOS中窦状卵泡颗粒细胞的凋亡增加,说明AnnexinⅠ参与了卵巢颗粒细胞的凋亡过程,并且发挥了重要作用。
Objective： To study the expression and biological significance of annexin I in the granulosa cell ofpolycystic ovarian syndrome （PCOS） in rat model. Methods： The expression of annexin I was detected by immunohistochemical method, and the quantitative analysis was performed by the gray value in PCOS and control group. Results： The annexin I expressed in different classes of preantral follicles in both PCOS group and control group. When the diameter of the follicle reached to 60-120um, the annexin I expression had significant difference between the PCOS group and control group （P〈0.05）. Conclusion： The annexin I expression evidently increased in sinusoid follicle and the granulosa cell of apoptosis raised m PCOS group ,which illuminated annexin I paticipated in the process of apoptosis in granulosa cell and played an imrnportant role.
出处
《现代生物医学进展》
CAS
2011年第18期3434-3437,共4页
Progress in Modern Biomedicine
基金
内蒙古自治区卫生厅科技项目(NJZY2010224)
