摘要
目的:探讨细胞凋亡在星形细胞瘤中的作用及其与p53、Fas和Fas配体(Fas ligand,FasL)的关系。方法:对43例星形细胞瘤的标本分别进行HE染色,TUNEL及免疫组化分别标记p53,Fas和FasL。结果:高级别肿瘤和低级别肿瘤间的凋亡无显著差异(P>0.05)。高级别星形细胞瘤的p53,Fas和FasL的表达均显著高于低级别肿瘤(P均<0.05)。结论:突变型p53可作为评价星形细胞瘤生物学行为的参考指标。与低级别星形细胞瘤相比,高级别肿瘤中的细胞凋亡受到了抑制,且Fas与FasL的过表达对细胞凋亡可产生明显影响。
Objective： To investigate the role of apoptosis in the progression of astrocytomas and its correlation with the expression of p53 and Fas/FasL. Methods： Histopathological analysis, TUNEL labeling and immunohistochemical staining of p53 and Fas/FasL. Results： Apoptosis was not significantly different in the two groups（ P〉0.05 ）; Expression of p53, Fas and FasL was significantly higher in the high-grade astrocytomas than the low-grade ones （P〈0.05）. Conclusion： p53 can serve as an informative parameter to evaluate the biological behavior of astrocytomas, Apoptosis may be suppressed in high-grade astrocytomas, the expression of the Fas/FasL aslo exert remarkable influence on apoptosis in the astrocytomas.
出处
《现代生物医学进展》
CAS
2011年第18期3501-3503,3539,共4页
Progress in Modern Biomedicine
基金
哈尔滨市科技创新人才专项资金项目(RC2010XK004048)
