摘要
目的:探讨子宫内膜癌患者P16基因甲基化和血清CA125检测的临床意义。方法:采用DNA甲基化特异性PCR分别对46例子宫内膜癌及12例正常内膜对照组织中抑癌基因p16甲基化进行检测;对所有病例术前均测定血清CA125水平。结果:子宫内膜癌组p16甲基化率45.6%,而12例对照组织均未检测到甲基化;子宫内膜癌组血清CA125水平明显升高。结论:子宫内膜癌患者p16基因甲基化和血清CA125水平与发病关系密切,两者结合对早期诊断及预后判断具有一定的临床指导意义。
Objective： To investigate endometrial cancer P16 gene methylation and the clinical significance of serum CA125. Methods： The detection of 46 cases of endometrial cancer and 12 normal endometrial tissue in the tumor suppressor gene p16 DNA methylation using methylation-specific PCR; in all cases before surgery were serum CA125 level. Results： Endometrial cancer group 45.6% rate of p16 methylation, while 12 cases were not detected in control tissue methylatinn; serum CA125 levels were significantly increased in endometrial cancer group. Conclusion： The endometrium cancer patient p16 gene methylation and the blood serum CA125 level morbidity relations are close, Both union has certain clinical guiding sense to the early diagnosis and the prognosis judgment.
出处
《现代生物医学进展》
CAS
2011年第18期3550-3552,共3页
Progress in Modern Biomedicine
