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Ghrelin发现和结构的研究现状 被引量：3

The discovery and structure of Ghrelin
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摘要 Ghrelin是生长激素促分泌素受体(growth hormone secretagogue receptor,GHSR)的内源性配体,是1999年由Kojima等[]人从大鼠胃组织中发现的含28个氨基酸的多肽,主要由胃黏膜泌酸腺X/A样细胞分泌并通过与其特异性受体结合而产生多种生物学效应。本文总结了近几年的文章,旨在通过对Ghrelin的发现和结构的介绍,为以后的相关研究奠定基础。 Ghrelin is the endogenic ligand of growth hormone secretagogue receptor （GHSR）, it was detected in stomach of mouse by Kojima in 1999 for the first time, it is a polypeptide which has 28 amino acids. Ghrelin is excreted by X/A cells in stomach mucous membrane secretory and do the deed through combing with its specificity antibody. The article summarizes many papers which appeard in recent years and wants to lay the foundation of correlational investigation.
作者 王丽晔 李峰 宋月晗 马佳美 李思耐 关冰河
机构地区 北京中医药大学
出处 《现代生物医学进展》 CAS 2011年第18期3589-3591,共3页 Progress in Modern Biomedicine
基金 北京中医药大学自主课题(52202)
关键词 GHRELIN 脑肠肽 结构 Ghrelin Braingut petide Structure
分类号 Q74 [生物学—分子生物学]
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参考文献23

  • 1Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-re- leasing acylated peptide from stomach [J]. Nature, 1999, 402(6762): 656-660.
  • 2Bowers CY. Unnatural growth hormone-releasing peptide begets na- trual ghrelin[J]. J Clin Endocrinol Metab, 2001, 86(4): 1464-1469.
  • 3Smith RG, Cheng K, Schoen WR, et al. A nonpeptidyl growth hor- mone secretagogue[J]. Science, 1993, 260(5114): 1640-1643.
  • 4Howard AD, Feighner SD, Cully DP, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release[J]. Science, 1996, 273(5277): 974-977.
  • 5Wajmajch M, Ten S, Gertner J, et al. Genomic Organization of the hu- man GHRELIN gane[J]. J Endoer genet, 2000, 1:231-233.
  • 6Wei W, Wang G, Qi X, et al. Characterization and regulation of the rat and human ghrelin promoters [J]. Endocrinology, 2005, 146 (3): 1611-1625.
  • 7Kanamoto N, Akamizu T, Tagami T, et al. Genomic structure and characterization of the 5'-flanking region of the human ghrelin gene [J]. Endocrinology, 2004, 145(9): 4144-415.
  • 8Bednarek MA, Feighner SD, Pong SS, et al. Structure-function studies on the new growth hormone-relesing peptide, ghrelin: minimal se- quence of ghrelin necessary for activation of growth hormone secreta- gogue receptor 1 α[J]. J Med Chen,2000, 43(23): 4370-4376.
  • 9尹雪丰,李茵,张炜真.Ghrelin的合成与分泌及其影响因素[J].生理科学进展,2009,40(3):241-244. 被引量：9
  • 10Hosoda H, Kojima M, Matsuo H, et al. Purification and characteriza- tion of rat des-Gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor [J]. J Boil Chem, 2000, 275 (29): 21995-22000.

二级参考文献10

  • 1Wei W, Wang G, Oi X, et al. Characterization and regulation of the rat and human ghrelin promoters. Endocrinology, 2005, 146 : 1611- 1625.
  • 2Kanamoto N, Akamizu T, Tagami T, et al. Genomic structure and characterization of the 5 '-flanking region of the human ghrelin gene. Endocrinology, 2004, 145 : 4144- 4153.
  • 3Yang J, Brown MS, Liang G, et al. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell, 2008, 132 : 387 - 396.
  • 4Gutierrez JA, Solenberg PJ, Perkins DR, et al. From the Cover: Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci USA, 2008. 105 : 6320 -6325.
  • 5Toshinai K, Mondal MS, Nakazato M, et al. Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun, 2001, 281 : 1220- 1225.
  • 6Hagemann D, Holst JJ, Gethmann A, et al. Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion. Regul Pept, 2007, 143 : 64 -68.
  • 7Kempa A, Krzyzanowska-Swiniarska B, Miazgowski T, et al. Not insulin but insulin sensivity, leptin, and cortisol are major factors regulating serum acylated ghrelin level in healthy women. J Endocrinol Invest, 2007, 30 : 659- 665.
  • 8Zhao Z, Sakata I, Okubo Y, et al. Gastric leptin, but not estrogen and somatostatin, contributes to the elevation of ghrelin mRNA expression level in fasted rats. J Endocrinol, 2008, 196 : 529 - 538.
  • 9Sakata I, Tanaka T, Yamazaki M, et al. Gastric estrogen directly induces ghrelin expression and production in the rat stomach. J Endocrinol, 2006, 190:749-757.
  • 10Hosoda H, Kangawa K. The autonomic nervous system regulates gastric ghrelin secretion in rats. Regul Pept, 2008, 146 : 12-18.

共引文献8

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二级引证文献2

现代生物医学进展
2011年 第18期

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