1340例胃癌根治术后患者预后的多因素分析

The multivariate prognostic analysis of 1 340 gastric cancer patients who received radical resection

目的:探讨影响胃癌根治术后患者预后的因素。方法:完整随访2005年1月～2009年12月于南京医科大学第一附属医院行胃癌根治术的1 340例患者(Ⅰ～Ⅲ期),对其临床病理特征和术后辅助化疗等因素进行统计分析。结果:1 340例患者目前存活956例,死亡384例,总体术后1、3、5年累积生存率分别为87%、63%、52%。单因素、多因素分析显示,年龄、肿瘤直径、脉管神经侵犯、浸润深度、区域淋巴结转移数目及TNM分期是胃癌根治术患者的独立预后因素(P<0.05)。结论:年龄、肿瘤直径、脉管神经侵犯、浸润深度、转移淋巴结数目及TNM分期能为临床判断胃癌预后及选择合理治疗方案提供参考。

Objective： To analyze the prognostic factors of the gastric cancer patients after radical surgery.Methods： A total of 1 340 gastric cancer patients who received radical resection from Jan.2005 to Dec.2009 were enrolled.The data concerning clinicopathological factors and adjuvant chemotherapy were analyzed retrospectively.Results： Among 1 340 patients,384 cases died and 956 patients are still alive.The overall survival rate for 1,3,5 years are 87%,63%,52% respectively.The results of univariate and multivariate analysis indicated that age,tumor size,lymphatic metastasis,blood vessel and perineural involvement,depth of invasion,number of metastatic nodes,TNM stages were recognized as significant independent prognostic factors（P 0.05）.Conclusion： Age,tumor size,lymphatic metastasis,blood vessel and perineural involvement,depth of invasion,number of metastatic nodes and TNM stage can be helpful for prognosis and treatment regimen of gastric cancer patients who received radical resection.