不同喜树碱制剂对普通小球藻的毒性比较

Comparative study on toxicity of various camptothecin formulations on Chlorella vulgaris

以普通小球藻(Chlorella vulgaris)为试验材料,连续10d测定了新型生物农药喜树碱3种不同的制剂对普通小球藻的毒性.结果表明:0.2%喜树碱乳油对普通小球藻毒性最高(EC50值在0.0368～0.2547mg.L-1),其中第3天的EC50值最小为0.0368mg.L-1;0.5%喜树碱钠盐的毒性较低(EC50值在0.6659～2.3104mg.L-1),比较稳定,其中7d的EC50值最大;2～6d的0.5%喜树碱钾盐的毒性逐渐增加,第6天的EC50值最低为0.4684mg.L-1,第9天后由0.8024mg.L-1急剧增加至5.8423mg.L-1.比较而言,喜树碱钾盐毒性和钠盐毒性较低,乳油制剂毒性最高.

In order to determine the toxicity of three camptothecin formulations on Chlorella vulgaris,10-day tests were employed and data were determined every day.The results showed that 0.2% camptothecin EC had the highest toxicity to C.vulgaris in the 10d with EC50 values between 0.0368 mg.L-1 and 0.2547 mg.L-1,with the lowest value on the 3rd day.The toxicity of 0.5% camptothecin Na ＋ SL was low,with their EC50 value between 0.6659 mg.L-1 and 2.3104 mg.L-1.The toxicity of 0.5% camptothecin K ＋ SL increased gradually from the 2nd to the 8th days,with the lowest EC50 value of 0.4684 mg.L-1 on the 6th day.EC50 increased rapidly from 0.8024 mg.L-1 to 5.8423 mg.L-1on the 9th day.The results also showed that 0.5% camptothecin K ＋ and Na ＋ SL had the lowest toxicity,while the 0.2% camptothecin EC had the highest toxicity.