18F—FDGPET—CT双时相显像结合高分辨率CT诊断孤立性肺结节的价值

Dual phase time scan combine high resolution CT to diagnose solitary pulmonary nodule by 18F- FDG PET-CT

目的探讨18F—FDGPET—CT双时相显像结合高分辨率CT（HRCT）对孤立性肺结节（SPN）的鉴圳诊断价值。方法经CT证实符合SPN的病例173例，应用PET—CT技术对SPN病例进行双时相显像及同机HRCT，早期显像于注射18F—FDG后50～60min，并行HRCT，延迟显像于注射后2～2．5h进行，测定病灶两次显像的SUV，并计算两次显像SUV的变化率，根据病灶HRCT的形态学特征，进行综合诊断判断良恶性，所得结果与随访结果作对照比较。结果173例SPN患者绐病理或随访证实恶性病变41例、良性病变132例。恶性病变组早期显像的SUV为6．26±0．72，延迟显像的SUV为6．88±0．74，滞留指数为（42．50±3．87）％；良性病变组早期显像的SUV为2．84±0．41，延迟硅像的SUV为2．73±0．36，滞留指数为（26．90±7．23）％。结论18F—FDGPET—CT双时相显像结合HRCT鉴别诊断SPN的方法简便、准确率高，具有广泛的临床实用价值。

Objective To evaluate the role of dual phase scan combine high resolution computerized tomography （HRCT） by 18F-FDG PET-CT imaging in the diagnosis of solitary pulmonary nodule（SPN）. Methods 173 patients with SPN demonstrated by CT, All these patients underwent dual time point combine HHCF 18F-FD（; PET/CT imaging. The imaging protocol included the early imaging combine HRCT of PET- CT at 50-60 min and delayed imaging of PET at 2-2.5 h post injection 18F-FDG. The standardized uptake value （SUV） was calculated for both time points. All results were expressed as the percentage change in SUV. According to characteristic in focal morphology by HRCT found, general inspection and diagnosis were benign or malignant,h was compared the resuh and following up result. Results Histopathology demonstrated or tollowing up result 41 patients with malignant lesions and 132 patients with benign lesions. The SUV of malignant lesions was SUV 6.26±0.72 in early imaging,, and 6.88±0.74 in delayed imaging. The retention index of malignant lesions was（42.50±3.87）%. The SUV of benign lesions was 2.84±0.41 in early imaging, and 2.73±0.36 in delayed imaging. The retention index of benign lesions was （26.90±7.23）%. Conslusions 18F-FDG PET-CT dual time point imaging combine HRCT is a simple practical method and accurate ratio high tot the diagnosis of SPN. The method will be widely clinically practised.