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SELEX技术中分离方法的研究进展 被引量：3

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摘要 指数富集配体的系统进化（systematicevolutionofligandsbyexponentidenrichment，SELEX）技术是一种用特定的随机寡核苷酸文库，并结合体外PCR扩增，经过多轮筛选，筛选出能与靶分子高亲和、高特异性结合的寡核苷酸序列[该序列被称为适配体（aptamer）]的技术。适配体类似于抗体，但优于抗体，有可能代替抗体应用于临床诊断和疾病的治疗。SELEX技术问世20年来，适配体的应用前景吸引着众多研究者不断探索，
作者 邵可可 王惠民 马达
机构地区 盐城市第一人民医院检验科 南通大学附属医院检验科
出处 《临床检验杂志》 CAS CSCD 北大核心 2011年第6期463-465,共3页 Chinese Journal of Clinical Laboratory Science
基金 江苏省医学重点学科建设资助项目(XK200723)
关键词 指数富集配体进化技术 适配体 随机寡核苷酸文库
分类号 Q789 [生物学—分子生物学]
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参考文献24

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二级参考文献29

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共引文献9

同被引文献41

  • 1王海英,于春宝,王燕,王新锋,高绪胜,刘志敏.TB-SA抗体检测对结核病临床诊断价值的研究[J].中国防痨杂志,2008,30(1):33-36. 被引量：21
  • 2胡忠义.结核病免疫学诊断技术研究进展[J].中国防痨杂志,2005,27:6-7.
  • 3端木宏谨,屠德华,张培元,等.临床技术操作规范结核病分册[M].北京:人民军医出版社,2004:25-41.
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引证文献3

二级引证文献4

临床检验杂志
2011年 第6期

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