血液净化的抗凝治疗

目的探讨低分子肝素钙在连续性血液净化治疗抗凝中的疗效及安全性。方法 60例行血液净化患者随机分为普通肝素(UFH)组和低分子肝素钙(LMWH)组,每组各30例。检测两组患者的活化部分凝血活酶时间(APTT)、血管路动脉压、静脉压变化;两组患者穿刺点平均压迫时间和出血情况。结果 LMWH组和UFH组相比,动静脉端APTT变化差异无显著性(P>0.05),但出血例次明显减少,并且穿刺点压迫时间明显缩短。结论低分子肝素钙在血液净化中抗凝效果明显,同时能减少患者出血的危险性。

Objective To observe the efficacy and safety of LMWH anticoagulation in continuous blood purification.Methods 60 patients were randomly divided into routine blood purification UFH group and LMWH group,30 cases in each.To detecte in patients with APTT,blood vessels Road arterial pressure,venous pressure changes;two groups of patients the average compression time and puncture site bleeding.Results LMWH group and UFH group,changes in arterio-venous side APTT was no significant difference（P0.05） ,but patients with bleeding times significantly reduced,and the puncture site compression time was significantly shortened.Conclusion LMWH anticoagulant in blood purification effect is obvious,and can reduce the risk of bleeding in patients.