双歧醋对大鼠预防性减肥的实验研究

Prophylactic antiobesity effect of bifidobacterium vinegar in rats

目的探讨双歧醋预防大鼠肥胖的作用及相关机制研究。方法 48只SD大鼠被随机分成双歧醋低剂量组[1.8 mL/(kg.BW)]、中剂量组[3.4 mL/(kg.BW)]、高剂量组[6.8 mL/(kg.BW)]和市售醋组[3.4mL/(kg.BW)]、肥胖模型组以及基础对照组,进行预防性减肥实验,观察双歧醋在大鼠肥胖过程中对大鼠的影响,测定指标包括大鼠体重、体脂、Lee's指数、脂肪细胞直径、血瘦素、血胰岛素。结果实验结果显示,双歧醋各组所有测定指标值都较肥胖组有明显好转,特别是血瘦素和血胰岛素水平,双歧醋的高、中剂量组与市售醋组差异有统计学意义。结论双歧醋能有效预防血瘦素和血胰岛素的升高,预防体脂、Lee's指数和体重的增加也有一定作用。

Objective To discuss the prophylactic antiobesity effect of bifidobacterium vinegar and possible mechanism.Method 48 SD rats were randomly divided into 6 groups： bifidobacterium vinegar groups of three different doses,ordinary vineger group,obesity model group and control group.The effect of bifidobacterium vinegar on the rats was observed;indicators including body weight,body fat,adipocyte diameter,Lee＇s index,leptin and insuline were determined.Result All indicator values measured were improved obviously compared with obesity model group.Particularly,the leptin and insuline levels of high and medium dosage bifidobacterium vinegar groups were improved obviously compared with those of ordinary vineger group.Conclusion Bifidobacterium vinegar can prevent the development of high leptin,insulin,and prevent the body weight,Lee＇s index and body fat from increasing to some degree.