氨溴索与碳酸氢钠序贯灌洗佐治支气管扩张感染疗效分析

Adjunctive treatment of bronchiectasis infection with ambroxol and sodium bicarbonate through sequential lavage:an efficacy analysis

目的探讨氨溴索与碳酸氢钠灌洗治疗支气管扩张反复感染的疗效及意义。方法将支气管扩张反复感染住院患者,分为灌洗组(常规治疗方法 +支气管局部注药灌洗34例)、对照组(常规治疗方法 38例),治疗2周后进行临床评估,随访半年。结果灌洗组总有效率与对照组相比差异有统计学意义(P<0.05),半年急性加重次数与对照组相比差异有统计学意义(P<0.01)。结论在常规治疗基础上局部氨溴索、碳酸氢钠序贯灌洗能提高支气管扩张感染疗效、减少半年急性加重次数、改善生活质量,通过改善微环境来维持菌群平衡值得借鉴、推广。

Objective To investigate the efficacy and significance of ambroxol and sodium bicarbonate through sequential lavage in treatment of bronchiectasis infection.Method The patients were randomly divided into conventional treatment group（control group） and the other group which combined conventional therapy with adjunctive therapy of ambroxol and sodium bicarbonate through sequential lavage（observation group）.The clinical efficacy ofthe two groups were analyzed after 2 weeks and the frequency of exacerbation were followed up in six months.Result The total effective rate and half year frequency of exacerbation of the observation group,compared with the control group,were significantly different（P0.05,P0.01）.Conclusion The adjunctive therapy of ambroxol and sodium bicarbonate through sequential lavage based on conventional therapy can enhance the curative effectiveness,reduce the frequency of acute exacerbation,and improve the half-year quality of life in bronchiectasis infection.