哮喘慢性持续期肺功能与生存质量的关系

Correlation between lung function and life quality of the patients with asthma in chronic duration

目的:探讨哮喘慢性持续期肺功能与生存质量的关系。方法:120例确诊为哮喘慢性持续期的患者填写哮喘生存质量问卷(AQLQ),记录日间及夜间症状评分并进行肺功能测试,其中99例经规范治疗(90 ± 15) d后依嘱复诊并再次填写AQLQ量表,记录日间及夜间症状评分并进行肺功能测试。按FEV1占预计值百分比(FEV1%)将治疗前后的患者各分为两组, FEV1%≥80%为A组, FEV1%≤79%为B组。观察患者肺功能与生存质量的关系。结果:无论治疗前还是治疗后,A组FEV1、FEV1%、PEF、PEF %和AQLQ均显著高于B组(P < 0.05),且AQLQ得分与FEV1%和PEF %结果高度一致;治疗前,AQLQ得分与FEV1(r =0.84)、FEV1%(r = 0.65)、PEF(r = 0.63)和PEF% (r = 0.44)均呈正相关(P < 0.01),治疗后,AQLQ得分仍与FEV1(r = 0.89)、FEV1%(r = 0.77)、PEF(r = 0.62)和PEF% (r = 0.50)呈正相关(P < 0.01)。结论:哮喘患者肺功能与生存质量密切相关,肺功能联合生存质量量表能更全面地反映患者病情的严重程度。

Objective To investigate the correlation between lung function and life quality of the patients with asthma in chronic duration.Methods 120 patients who were diagnosed as asthma and asked to fill in the asthma quality of life questionnaire （AQLQ）,and test pulmonary function simultaneously,their daytime and nighttime symptom scores were also recorded respectively.After （90 ± 15） days＇ regular treatment,99 cases of them filled in the AQLQ scale and received pulmonary function test once again.The patients were divided into two groups depending on FEV1% before or after treatment respectively,FEV1% ≥ 80% for the A group,FEV1% ≤ 79% for the B group,so as to observe the correlation between lung function and life quality.Results No matter before or after treatment,FEV1,FEV1%,PEF,PEF% or AQLQ score showed significant difference （P 0.05） between the two groups and the AQLQ showed a good correlation and consistency with FEV1% and PEF%.AQLQ was positively correlated with FEV1,FEV1%,PEF,PEF% and there was significant difference（P 0.05）.Conclusion The pulmonary function of asthmatic patients is closely related with the quality of life,it is more comprehensively assess the severity of patients to joint the pulmonary function and the AQLQ score.