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Notch信号通路在肿瘤治疗中的研究进展 被引量：4

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摘要 跨膜受体蛋白Notch信号通路的活性在决定细胞命运（包括增殖、分化以及凋亡）过程中发挥着重要作用,它的功能异常将导致未分化细胞向肿瘤细胞转化。人类许多肿瘤中均可检测到Notch信号通路活性的改变,
作者 刘尚文 张旭
机构地区 解放军总医院泌尿外科
出处 《实用医学杂志》 CAS 北大核心 2011年第19期3609-3611,共3页 The Journal of Practical Medicine
关键词 NOTCH信号通路 肿瘤细胞转化 未分化细胞 治疗 跨膜受体蛋白 功能异常 活性
分类号 R730.5 [医药卫生—肿瘤]
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参考文献21

  • 1Cook M,Yu X M,Chen H.Notch in the development of thyroid C-cells and the treatment of medullary thyroid cancer[J].Am J Transl Res,2010,2(1):119-125.
  • 2Chen Y,Li D,Liu H,et al.Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells[J].Cancer Biol Ther,2011,11 (1):14-21.
  • 3Panelos J,Massi D.Emerging role of Notch signaling in epidermal differentiation and skin cancer[J].Cancer Biol Ther,2009(8):1986-1993.
  • 4Kang J H,Lee E H,Park S W,et al.MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways[J].J Immunol,2011,187 (1):22-229.
  • 5Yeh T S,Wu C W,Hsu K W,et al.The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2[J].Cancer Res,2009,69(12):5039-5048.
  • 6Shi T P,Xu H,Wei J F,et al.Association of low expression of notch-1 and jagged-1 in human papillary bladder cancer and shorter survival[J].J Urol,2008,180(1):361 -366.
  • 7Yeasmin S,Nakayama K,Rahman M T,et al.Expression of nuclear Notch3 in cervical squamous cell carcinomas and its association with adverse clinical outcomes[J].Gynecol Oncol,2010,117(3):409-416.
  • 8Bardelli A,Siena S.Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer[J].J Clin Oncol,2010,28 (7):1254-1261.
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同被引文献60

  • 1付亚娟,叶枫,吕卫国,谢幸.Notch信号通路的研究现状[J].医学分子生物学杂志,2007,4(5):447-450. 被引量：24
  • 2Radtkel F, Schweisguth F, Pear W. The Notch' gospel' [ J ]. EMBO Rep,2005,6 (12) : 1120-1125.
  • 3Nam Y, Weng AP, Aster J C, et al. Structural require- ments for assembly of the CSL Imracellular Notch Mastermind-likel transcriptional activation complex [ J ]. J Biol Chem ,2003,278 (23) :21232-21239.
  • 4Logeat F, Bessia C, Brou C, et al. The Notchl receptor is cleaved constitutively by q furin-like convertase [ J ]. Proc Natl Acad Sci USA,1998,95(14) :8108-8112.
  • 5Weinmaster G. Notch signal transduction: a real rip and more[ J]. Curt Opin Genet Dev,2000,10(4) :363-369.
  • 6Moloney DJ, Panin VM, Johnston SH, et al. Fringe is a glyeosyltransferase that modifies Notch [ J ]. Nature ,2000, 406 ( 6794 ) : 369 -375.
  • 7Fryer C J, White JB, Jones KA. Mastermind recruits Cy- cC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turn over[J]. Mol Cell,200g, 16(4) :509- 520.
  • 8Shi W, Harris AL. Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials [ J ]. J Mammary Gland Biol Neoplasia, 2006,11 ( 1 ) :41- 52.
  • 9Ordentlieh P, Lin A, ShenCP, et al. Notchinhibition of E47 supports the existence of a novel signaling pathway [ J ]. Mol Cell Biol, 1998,18 (4) :2230-2239.
  • 10Sander GR, Powell BC. Expression of notch receptors and ligands in the adult gut[ J]. J Histochem Cytochen,2004, 52(4) :509.

引证文献4

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实用医学杂志
2011年 第19期

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