盐酸利多卡因在高原藏族和汉族志愿者体内的药动学研究

The pharmacokinetics of Lidocaine hydrochloride in Tibetan and Han healthy volunteers living at high altitude

目的研究盐酸利多卡因在高原藏族和汉族健康志愿者体内的药动学特征。方法采用RP-HPLC法测定人血浆中药物浓度,色谱柱为Lichrospher C18(250 mm×4.6 mm,5μm),流动相为乙腈-甲醇-0.5%冰乙酸溶液(15∶20∶50)。结果藏族和汉族志愿者的t1/2分别为2.44±0.52、2.44±0.69 h,AUC0-t分别为7.08±1.32、7.43±1.86μg.h.mL-1,MRT0-t分别为2.50±0.25、2.37±0.31 h,Tmax分别为0.53±0.12、0.56±0.17 h,Cmax分别为2.74±0.57、2.78±0.54μg.mL-1,Cl分别为1.30±0.27、1.24±0.34 L.h-1,V分别为4.49±0.90、4.31±1.48 L。结论盐酸利多卡因在高原藏族和汉族健康志愿者体内的药动学特征无显著性差异。

OBJECTIVE To study the pharmacokinetics of Lidocaine hydrochloride in Tibetan and Han healthy volunteers living at high altitude.METHODS The plasma concentration of Lidocaine was determined by RP-HPLC method,the analysis involved a 250 mm×4.6 mm column packed with C18,the mobile phase consisted of acetonitrile-methyl alcohol-0.5%glacial acetic acid（15：20：50）.RESULTS The pharmacokinetics parameters t1/2,AUC0→t,MRT0→t,Tmax,Cmax,Cl and V in Tibetan and Han volunteers were 2.44±0.52 h and 2.44±0.69 h,7.08±1.32 μg·h·mL-1 and 7.43±1.86 μg·h·mL-1,2.50±0.25 h and 2.37±0.31 h,0.53±0.12 h and 0.56±0.17 h,2.74±0.57 μg·mL-1 and 2.78±0.54 μg·mL-1,1.30±0.27 L·h-1 and 1.24±0.34 L·h-1,4.49±0.90 L and 4.31±1.48 L,respectively.CONCLUSION The results demonstrated that there were no significant diffirence between the pharmacokinetics of Lidocaine in Tibetan and Han healthy volunteers living at high altitude.