电针刺预防胃肠道应激性黏膜损伤的机制

Mechanisms of electro-acupuncture in prophylaxis of stress-related mucosal damage

背景胃肠道在围手术期极易发生应激相关性的黏膜损伤（stress-related mueosal damage，SRMD），在多脏器功能障碍综合征（multiple organ dysfynction syndrome，MODS）发生、发展中的作用正日益引起人们的关注。目的就电针刺预防SRMD的可能相关作用机制进行综述。内容电针刺对应激性胃黏膜损伤具有一定的保护作用，其机制可能是通过减少胃酸分泌、增加胃黏液层和胃黏膜厚度、抑制活性氧（reactive oxygen species，ROS）生成和细胞内Ca^2＋超载、降低垂体-下丘脑-肾上腺轴的活动以及调控机体内源性内皮素-1／一氧化氮和环氧合酶2，前列腺素E水平等实现的。趋向SRMD形成机制比较复杂，而电针刺对其发挥的保护作用不能用单一的机制解释，可能是多种机制共同参与的结果。

Background Stress-related mucosal damage （SRMD） is a very common complication during the perioperative period, and it plays a great role in the initiation and progression of multiple organ dysfynction syndrome （MODS）. Objective This review summarized the mechanisms of electro-acupuncture in prophylaxis of stress-related mucosal damage. Content Electroacupuncture has a protective effect on stress gastric mucosal injury, which may be by reducing gastric acid secretion, increasing gastric mucus layer and mucosal thickness, inhibited reactive oxygen species （ROS） production and intracellular Ca^2＋ overload and reduce HPA axis activity and regulation of body ET-1/NO and COX-2/PGE2 endogenous levels achieved. Trend The mechanism of SRMD is very complex, and the protective effect of electroacupuncture on stress gastric mucosal injury is not unique to one single reason, maybe the combination of some mechanism.