代谢综合征患者血清胆红素与颈动脉内膜中层厚度关系

Relationship between serum bilirubin and carotid artery intima-media thickness in patients with metabolic syndrome

目的：探讨代谢综合征（MS）患者血清胆红素与颈动脉内膜中层厚度（IMT）关系。方法：记录60例代谢综合征（MS）患者体重、身高、血压，测定血糖、血脂、血清胆红素。根据颈动脉IMT值，分为内膜正常组（18例）、内膜增厚组（22例）、斑块组（20例），并对上述指标进行比较。结果：与内膜正常组和内膜增厚组比较，MS患者斑块组总胆红素[TBIL，（17．99±6．15）μmol／L比（14．10±6．24）μmol／L比（10．59±5．86）μmol／L]、间接胆红素[IBIL，（13．17±5．13）μmol／L比（9．78±5．18）μmol／L比（6．79±5．10）μmol／L]明显降低（P〈0．05～0.01），且内膜增厚组TBIL、IBIL明显低于内膜正常组（P〈0．05）。结论：代谢综合征患者颈动脉粥样硬化越重，血清胆红素水平越低。

Objective： To study the relationship between serum bilirubin and carotid artery intima-media thickness （IMT） in patients with metabolic syndrome （MS）. Methods： Weight, height, blood pressure, blood sugar, blood lipid and serum bilirubin were measured and recorded in 60 MS patients. According to carotid artery IMT, they were divided into normal intima group （n= 18）, thickened intima group （n：22） and plaque group （n=20） . All above indexes were compared and analyzed. Results： Compared with normal intima group and thickened intima group, there were significant decrease in total bilirubin [TBIL, （17.99±6.15） /μmol/L vs. （14. 10±6.24） μmol/L vs. （10.59±5.86） μmol/l] and indirect bilirubin [IBIL, （13.17±5. 13） /,mol/L vs. （9.78±5. 18） μmol/L vs. （6.79±5.10） μmol/L] in plaque group （P〈0.05-〈0.01）, and TBIL and IBIL of thickened intima group were significantly lower than those of normal intima group （P〈0.05）. Conclusion： The more severity of carotid atherosclerosis, the lower serum bilirubin level in patients with metabolic syndrome.