维吾尔族冠心病心力衰竭患者血浆纤维蛋白原与血清尿酸水平的分析

Analysis of levels of plasma fibrinogen and serum uric acid in Uygur nationality patients with coronary heart disease and heart failure

目的:探讨维吾尔族男性冠心病心力衰竭患者血浆纤维蛋白原(Fg)与血清尿酸(UA)浓度的变化。方法:237例维吾尔族男性冠心病患者,按左室射血分数(LVEF)分为LVEF>50%组(对照组,86例)和心衰组(LVEF≤50%,151例),心衰组又分为40%<LVEF≤50%组(70例),与LVEF≤40%组(81例),并根据有无糖代谢异常分为两组,比较不同组间Fg与UA含量的变化。结果:LVEF>50%组Fg含量[(3.33±0.54)g/L]明显低于心衰两组[(3.54±0.58)g/L,(3.70±0.64)g/L,P<0.05],在心衰两组间差别无显著性(P=0.092);三组UA浓度随LVEF值降低明显升高[(324.55±51.65)mmol/L比(358.21±39.72)mmol/L比(375.57±63.13)mmol/L,P<0.05];与无糖代谢异常组比较,糖代谢异常组Fg[(3.39±0.60)g/L比(3.65±0.58)g/L]、UA[(333.47±53.40)mmol/L比(372.60±53.95)mmol/L]含量均明显升高(P<0.01);偏相关分析表明Fg和UA水平无显著相关性(r=0.08,P=0.23);Fg、UA与LVEF均呈负相关(r=-0.257,-0.41,P均<0.001)。结论:冠心病患者血浆纤维蛋白原和血清尿酸含量显著增加,与心力衰竭密切相关,是心功能恶化的预测因子,其中尿酸变化更明显;糖代谢异常患者较糖代谢正常者纤维蛋白原与尿酸含量更明显增加。

Objective： To investigate changes of concentrations of plasma fibrinogen （Fg） and serum uric acid （UA） in Uygur nationality male patients with coronary heart disease （CHD） and heart failure （HE）. Methods： According to left ventricular ejection fraction （LVEF）, a total of 237 Uygur nationality male CHD patients were divided into LVEF 〉50% group （control group, n=86） and HF group [40〈LVEF≤50% sub group （n=70） and LVEF≤40% sub group in 81）]. According to abnormal glucose metabolism or not, all patients were divided into two groups and changes of concentrations of Fg and UA were compared among all groups. Results： In LVEF〉50% group, Fg level （3.33±0.54） g/L was significantly lower than those of two HF sub groups[ （3.54±0.58） g/L, （3.70±0.64） g/ L, P〈0.05], and there was no significant difference between two HF sub groups （P=0.092）; When LVEF decreased, UA Levels of the three groups significantly increased [ （324.55±51.65） mmol/L vs. （358.21±39.72） mmol/l, vs. （375. 57±63. 13） mmol/L, P〈0.05]; compared with normal glucose metabolism group, levels of Fg [ （3.39±0. （50） g/L vs. （3.65±0.58） g/L] and UA [（333.47±53.40） mmol/L vs. （372.60±53.95） mmol/L] sig nificantly incrcased in abnormal glucose metabolism group （P〈0. 01 ）; partial correlation analysis showed no signifi cant correlation between Fg and UA （r= 0.08, P = 0.23）; both Fg and UA levels were negatively correlated with LVEF （r=0. 257, -0.41, P〈0. 001）. Conclusion： Levels of plasma Fg and serum UA are increase and closely re lated with HF, and are predictors of heart failure. Change of UA is more obvious in CHD patients; whereas levels of Fg and UA more significantly increase in patient with abnormal glucose metabolism.