79例新疆维吾尔族多发性大动脉炎的临床特点分析

Clinical characteristics of Takayasu′s arteritis in 79 Uygur nationality patients in Xinjiang

目的:探讨新疆维吾尔族患者多发性大动脉炎(Takayasu′s arteritis,TA)的临床特点。方法:回顾性分析1996年1月至2009年6月期间诊断为TA的79例患者的临床资料,比较新疆维吾尔族男女患者TA临床特点的差别。结果:本研究中男女患者比例为1∶3.9;男性患者发病年龄显著大于女性患者[(32±13)岁比(24±9)岁,P<0.05],40岁以上发病的男性占29.4%,女性占4.8%(P<0.05);与男性患者比较,女性患者处于病情活动期的显著增加(47.1%比75.8%);血沉(17.6%比62.9%),C反应蛋白(11.8%比51.6%),白细胞计数(17.6%比40.3%)均显著增加(P均<0.05)。男女患者血管受累部位、分型比例无显著差别(P>0.05)。结论:新疆维吾尔族多发性大动脉炎患者以女性为主,发病年龄早于男性,病情多处于活动期。

Objective： To investigate the clinical characteristics of Takayasu＇s arteritis （TA） in Uygur nationality pa tients in Xinjiang. Methods： Clinical data of 79 patients diagnosed as TA from January 1996 to June 2009 were retro spectively analyzed. Difference between clinical characteristics of male and female Uygur nationality patients were compared and analyzed. Results： Ratio of male/female patients was 1 ： 3.9 in our study; onset age of male patients was significantly older than that of female patients [ （32±13） years vs. （24±9） years, P〈0.05], 29.4% male patients and 4.8% female patients fell ill over 40 years old （P〈0.05） ; 75.8% female patients and 47.1% male patients were in active phase （P〈0.05）; compared with male patients, the blood sedimentation （17.6% vs. 62.9%）, C--reactive protein （11.8% vs. 51.6%） and white blood cell count （17.6%o vs. 40.3%） significantly increased in female patients （P〈0.05 all） . Ratios of typing and sites of vascular lesion were no significant difference between male and female patients （P〉0.05）. Conclusion： Patients with Takayasu＇s arteritis are mainly female in Xinjiang Uygur nationality; female patients are often in active disease and fall ill at a younger age than male patients.