通滞苏润江滴丸成型工艺

Moulding Process of Tongzhi Surunjiang Dropping Pills

目的:确定通滞苏润江滴丸的最佳成型工艺。方法:采用单因素及正交试验设计,以滴丸的圆整度、硬度、溶散时限、丸重差异为评价指标,优选滴丸成型的药液温度、冷却温度、滴头口径、滴速、滴距等工艺条件。结果:确定最优滴丸成型工艺为药粉与PEG4000配比1∶1.5,滴头内/外径2.5/3.0 mm,冷却剂为二甲基硅油,冷却液温度10℃,药液温度90℃,滴速40滴/min,滴距6 cm。结论:优选的通滞苏润江滴丸制备工艺稳定、可行。

Objective：To determine the optimum moulding process of Tongzhi Surunjiang dropping pills.Method：Single experiment and orthogonal design were used to optimize temperature of drug liquid,temperature of cooling,internal and external diameter of emitter,dropping distance and dropping rate.Roundness,hardness,resolving time and pill weight difference were used as criteria.Result：The optimum moulding process was as follow：PEG4000-drug was 1.5∶1,internal and external diameter of emitter were 2.5 mm and 3.0 mm,dimethyl silicone oil was coolant,temperature of cooling liquid was 10 ℃,temperature of drug liquid was 90 ℃,dropping rate was 40 drops·min-1,dropping distance was 6 cm.Conclusion：This process is stable and feasible.