姜黄消痤搽剂对大、小鼠炎症组织的抗炎作用

Anti-inflammatory Effect of Jianghuang Xiaocuo Chaji

目的:研究姜黄消痤搽剂的抗炎机制。方法:注射卵白蛋白(ovalbumim,OA)致小鼠足肿胀,观测姜黄消痤搽剂1.35,0.90,0.45 mg.kg-1外用,3次/d,连续4 d,对OA引起足肿胀的影响,检测炎症组织中前列腺素E2(PGE2)的含量;福氏完全佐剂(FCA)致大鼠关节炎,1.35,0.90,0.45 mg.kg-1外用,2次/d,连续30 d,检测致炎部位皮肤和皮下组织的病理改变和白细胞介素(IL-2)含量。结果:姜黄消痤搽剂可显著抑制OA引起足肿胀,并能降低炎症组织中PGE2的含量;对OA致敏激发皮炎皮损组织有明显治疗作用;可减轻FCA所致炎症反应并降低炎症组织中IL-2的含量。结论:姜黄消痤搽剂可能通过抑制PGE2,IL-2的产生而发挥抗炎作用。

Objective：To study the anti-inflammatory effect of Jianghuang Xiaocuo Chaji.Method：Anti-inflammatory effect of Jianghuang Xiaocuo Chaji was studied on various experimental models.Result：Jianghuang Xiaocuo Chaji（1.35,0.90,0.45 mg·kg-1,externally used three times daily for 4 d） inhibited mice paw edema produced by ovalbum and reduced the production of prostaglandin-2（PGE2） in inflammatory tissues.In allergic arthritis mice,Jianghuang Xiaocuo Chaji（1.35,0.90,0.45 mg·kg-1 externally used twice daily for 30 d） could inhibit the dermal pathological changes and decrease the content of serum interleukin-2（IL-2）.Conclusion：Jianghuang Xiaocuo Chaji showed remarkable antiinflammatory effects,reduced the production of PGE2 and decreased the content of serum IL-2.