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急性毒性体内及体外替代方法研究进展 被引量：3

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摘要 急性毒性试验是毒理学安全性评价第一阶段基础性试验,是毒理学安全性评价制订卫生管理标准不可或缺的重要依据〔1〕,其主要目的是求出受试化合物对试验动物的半数致死剂量（LD50）。传统急性毒性试验虽然可较精确测量LD50,但以死亡为其观察终点，使用动物较多，工作量较大，耗费较多人力物力。
作者 曾丽海 杨杏芬 赵敏
机构地区 广东省疾病预防控制中心毒理所 中山大学公共卫生学院
出处 《中国公共卫生》 CAS CSCD 北大核心 2011年第10期1331-1333,共3页 Chinese Journal of Public Health
基金 国家卫生公益性行业科技专项经费资助(200802080)
关键词 急性毒性 体内替代 细胞毒性
分类号 R991 [医药卫生—毒理学]
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参考文献21

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共引文献65

同被引文献51

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引证文献3

二级引证文献19

中国公共卫生
2011年 第10期

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