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N-乙酰基转移酶多态性与膀胱癌易感性研究进展 被引量：1

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摘要 N-乙酰基转移酶(NAT)是体内重要的Ⅱ相代谢酶,主要存在于肝细胞中,催化乙酰基团从乙酰辅酶A转移到其作用底物芳香胺及杂环胺类物质上,在人体对芳香胺类致癌物的活化和/或灭活起着重要的作用。NAT的基因多态性与膀胱癌的遗传易感性密切相关,近年来成为国内外学者研究的热点。本文主要就NAT基因多态性与膀胱癌遗传易感性的研究现状作一综述。
作者 刘建 王大朋 安艳
机构地区 苏州大学医学部公共卫生学院
出处 《卫生研究》 CAS CSCD 北大核心 2011年第5期671-674,共4页 Journal of Hygiene Research
基金 日本文部科学省日本学术振兴会研究辅助金资助项目(No.20390173) 江苏省放射医学与防护重点实验室开放课题(No.KJS0927) 苏州大学国家自然科学基金预研项目(No.Q3126982)
关键词 N-乙酰基转移酶 基因多态性 膀胱癌
分类号 R737.14 [医药卫生—肿瘤]
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参考文献29

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二级参考文献25

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卫生研究
2011年 第5期

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