艾片的大鼠在体肠吸收动力学研究

Study on the Intestinal Absorption Kinetics of Aipian in Rats

目的:研究艾片的大鼠在体肠吸收动力学。方法:采用大鼠在体单向灌流实验,利用气相色谱法测定艾片中龙脑含量,分别研究灌流流速、药物浓度、吸收部位对艾片吸收的影响。结果:灌流流速、药物浓度、吸收部位对艾片吸收速度常数(Ka)和表观吸收系数(Papp)无显著性影响。结论:艾片的肠吸收机制为被动扩散,其吸收动力学符合一级方程。

OBJECTIVE： To investigate the intestinal absorption mechanism of Aipian in rats. METHODS： The rat single-pass intestinal perfusion technique was applied, and the concentration of borneol in Aipian was determined by GC ; the effects of perfusion rate, drug concentration, absorption site on Aipian absorption were studied. RESULTS： The perfusion rate, drug concentration and absorption site had no effect on the absorption rate coefficient （Ka） and apparent permeability coefficient （Papp）.CONCLUSION： The absorption of Aipian is up to the first-order kinetics and passive transport mechanism.